Diabetic Nephropathy Flashcards Preview

Renal > Diabetic Nephropathy > Flashcards

Flashcards in Diabetic Nephropathy Deck (10):
1

four main consequences of diabetes

ESRD, CV, Blindness, Amputation

2

what fraction of diabetics develop nephropathy

1/3, #1 cause of ESRD

3

Stage 1 (silent)

hyperfiltration and hypertrophy

4

stage 2 (Incipient)

normal GFR, microalbuminuria. MM expansion

5

Stage 3 (overt nephropathy)

macroalbuminuria (>300mg/day), renal insufficiency (HTN)

6

stage 4 (advanced nephropathy)

renal failure. possible nephrotic syndrome but declines as GFR falls very low (Scr >6, GFR<15ml/min).

7

cause of early hyperfiltration and later renal failure.

glomerular hypertrophy, afferent dilation, efferent constriction. Loss of functioning nephrons due to MM fibrosis

8

two main factors involved in nephropathy

VEGF: altered hemodynamics and barrier leads to albuminuria, TGF-beta: matrix proliferation leads to sclerosis and hypertrophy

9

Two main treatments

Tight glucose control (HbA1c<130/80

10

What is the renin state of diabetics

low systemic but high local. Block the RAS path but dont combine ACEI and ARB