Diarrheaviruses: Adenoviruses and Picornaviruses

Question 1

Adenovirus types?

Answer 1

~100 serotypes!

52 infect humans, split into 7 groups A - G

Question 2

Adeno Pathogenesis

Answer 2

infects mucoepithelial cells in resp tract, GI tract, and conjuctiva, causing cell damage.
disease determined by tropism of serotype.
persists in lymphoid tissue (tonsils, adenoids, peyer patches)
Antibody important for resolution (CMI also important tho)
causes characterstic inclusion bodies (dark spots in epithelial cells)

Question 3

Adeno transmission

Answer 3

Aerosols, fecal matter, close contact, dirty pools/ponds.

Question 4

Adeno epidemiology

Answer 4

most prevalent are serotypes 1 to 7.

Resp tract ones.

Question 5

Adeno Symptoms

Answer 5

Gastroenteritis and Diarrhea. Major cause of acute viral gastroenteritis.
Enteric adenovirus are type 40,41,42 (intestines)
Intussusception (folding of intestine in on itself)

Question 6

Adeno Diagnosis

Answer 6

ELISA and fluorescent antibody assay,
PCR and DNA prove.
viral isolaton cell cutlture

Question 7

Adeno Treatment

Answer 7

Cidofovir and ribavirin for the immunosurpessed.

Live oral vaccines (for 4+7 in military)

Question 8

Picornaviruses structure + features

Answer 8

small +ssRNA viruses, naked. icosahedral ~30 nm
>230 different viruses.
polio, coxsackie, echo,entero, rhino, etc etc.

Question 9

Picrona replication

Answer 9

genome is inserted alone, sufficient.
can be endocytosed as well.
virions released on cell lysis.