Diazepam Flashcards Preview

Pharm Oral Drugs > Diazepam > Flashcards

Flashcards in Diazepam Deck (11):
1

Brand Name

Valium

2

Class

Benzo

3

Structure

Benzene ring fused w/ 7 member diazepine ring

4

mechanism of action

potentiates binding of GABA to the GABA-A receptor, keeping the Cl- channels open and hyperpolarizing the cell, making it resistant to excitation

5

pharmacokinetics
PB
Lipid solubility
VD
elimination

highly PB
highly lipid soluble
large VD (0.7-1.7L/Kg)
rapidly crossed BBB and placenta
elimination - conjugated CYP450, excreted urine

6

pharmacokinetics
onset
doa
T1/2

onset - 30-60 sec
doa - prolonged
T1/2 - 21-37 hrs

7

active metabolite

desmethyldiazepam
most active, lasts 48-96 hrs

8

side effects

lowers CBF & CMRO2
does not cause isoelectric EEG
preserves CO2 response but flattens curve
neuroprotective

lowers SVR, BP, CO with induction dose

dose dependent decrease in RR and TV
does NOT attenuate SNS response to DVL
can cause hypersensitivity and paradoxical excitation

9

contraindications

early pregnancy
decrease dose for hepatic/renal impairment
use with caution in elderly (increased sensitivity)
DO NOT give with glaucoma

10

dose

pre-med 0.2 mg/kg IV; 10-15 mg PO
induction: 0.5-1 mg/kg IV

11

other

least potent benzo
pain on injection (propylene glycol)
does not effect NMB dose