DIC

Question 1

what are the signs and symptoms for DIC ?

Answer 1

if acute DIC

there is spontaneous bleeding
causing hypotension and shock

there is purpura rashes

shortness of breath.

digitial ischemia and gangrene

renal cortical necrosis = so there is kidney failure problems

adrenal infraction

Question 2

what are the different classification of DIC and what are they caused by ?

Answer 2

there is acute
caused by septicemia and infection such as neisseria meningitis meningococcemia

amniotic fluid embolsim

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chronic
cancer or liver diseases

Question 3

how can we diagnose DIC ?

Answer 3

platelets counts are decreases (150-400k / ul)

PT is prolonged (intrisic pathway)

aPTT is prolonged (extrinsic pathway )

FDP = fibrin degredated products
increased

fibrinogen = decreased

antithrombin 3 = markedly decreased

protien C = markedly decreased

in peripheral blood smear we see shcistocytes

Question 4

what is the treatment for DIC ?

Answer 4

treat the underlying problems

coagulation factor deficiency = fresh frozen plasma can be given

platelet transfusion

fibrinogen decreased = cryptopercipitate

when they produce serous clinical consequences such as ischemia = heparin is given ALWAYS MUST BE USED IN COMBINATION WITH REPLACMENT THERAPY MENTIONED ABOVE

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in chronic cases low dose heparin or low mocleular weight heaprin is enough