Differentiation and Functions of CD4+ T cells Flashcards Preview

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Flashcards in Differentiation and Functions of CD4+ T cells Deck (36):
0

The a/B TCR recognizes (binds to) both peptides presented within

MHC molecules and MHC itself.

1

a/B TCR are MHC restricted. T/F?

true.

2

What do you need to activate a T cell?

TCR, CD4 or CD8, and CD3

3

CD3 proteins have long cytoplasmic tails long enough to?

signal transduce

4

Langerhans' cells enter the Lymph node to become Dendritic cells expressing?

B7

5

B7- positive Dendritic cells stimulate which cell?

Naive T cells

6

Langerhans' Cells are immature Dendritic cells that do not express high levels of B7 when they are?

not activated by antigens in the skin

7

Naive T cells do not have which receptor IL expressed on their surface?

IL-2R

8

activated T cells produce large amounts of IL-2 and EXPRESS?

IL-2Receptor

9

This Interleukin regulates T cell growth factor and enhances resistance of apoptosis in activated T cells.

IL-2

10

Tuberculosis (intracellular pathogen) causes the immune response of which lymphocyte, cytokine, and interleukin?

Th1, IFN-y, and IL-12

11

Th2 cells secrete which cytokines in helminthic and allergic reactions?

IL-4, IL-5, and IL-13

12

Th17 cells secrete which cytokines in extracellular and autoimmune inflammatory disease?

IL-17a, IL-17f, and IL-22

13

activated T cells by Dendritic cells that secrete IL-23 lead to activation of which cell in Neutrophilic or Monocytic inflammation

Th17

14

secretion of IFN-y by Th1 cells activate these cells which lead to this antibody production

Macrophages that lead to IgG production

15

IL-5 is the major cytokine in this reaction?

Allergy rxns and Helminth infections

16

Antibody mediated immune response is activated by which cell?

Th2 cells

17

Cell-mediated immune response is activated by which cells?

Th1

18

Th17 cells are involved in?

inflammation and anti-bacterial response

19

the outcome of Th0 (immature effector T cell) generates several of these subsets

Th1, Th2, and Th17

20

PRR-signaling causes activation and maturation of

APC

21

which interleukin assists the development and differentiation of Th1 cells?

IL-12

22

IL-12 is produced by?

DC and Macrophages

23

IFN-y produced by NK cells activate which transcription factors?

T-bet, STAT1, and STAT4

24

Transcription factors activated by IFN-y stimulate the differentiation of Naive CD4+ T cells to which subset?

Th1

25

IL-4 is produced by?

Th2 cells

26

IL-4 inhibits the development of Th1 and Th17 cells produced by?

Th2 cells

27

IL-4 activates which transcription factors

GATA 3 and STAT 6 which stimulate differentiation of naive CD4+ t cells to the Th2 subset

28

IL-23 is the most important cytokine in differentiation of which cells?

Th17 cells

29

IL-1, IL-6, and IL-23 activate the transcription factors

RORyt and STAT 3 to stimulate the differentiation of Th17 cells

30

Macrophages release ROS, NO upon activation of these cells in Cell mediated immunity?

Th1 cells

31

Tissue repair from Collateral damage induced by IL4 and IL13 by activated

Macrophages

32

IL-1, IL-12, and IL-23 are important interleukins for

Inflammatory response

33

IL-10 and TGF-beta are important mechanisms for

anti-inflammatory effects, wound repair, and fibrosis

34

Alternatively activated macrophages (M2) are stimulated in

Collateral damage and anti-inflammatory responses

35

Epithelial cells produce anti-microbial peptides stimulated by?

IL-17