Disease AND specific terms - Block 1 Flashcards Preview

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Flashcards in Disease AND specific terms - Block 1 Deck (25):
1

Marfan syndrom
1. mutation of what
2. results in abn what
3. physio outcomes in patients (MN)

1. fibrillin gene,
2. ab elastic fibers
3. -elongated limbs
-aortic aneurysms (bulging of the aortic wall)
-dislocation of eye lens

*Marfan is a martian -> long limbs AND aneurysms AND dislocation of eye lens

2

give three examples of glycoproteins

1 FIBRO-NECTIN
2 laminin
3 C-HONDRO-NECTIN

3

GAG always has what in its name

sulfate

4

Proteoglycans
1. structure
2. purpose

1. Core protein with GAGs (sugar) attached along it.

2. provide structure to matrix and hold water.

5

two types of macromolecules
generated by fibroblasts ARE

glycoproteins
proteoglycans

6

type I hypersensitivity reactions
1. symptoms

2. caused by what (at cellular level)

3. example of common type 1 hypers rxn

1. swelling and itching

2. when mast cells dump its contents in EC space
read: anaphylactic shock results when there's extensive release of mediators

3. allergic rxn

7

if Na channels are blocked, threshold will go (up/down)

up

8

Bactin

bactin blocks Na channels on pain-sensing neurons

9

Ca is normally found where

EC

10

normal REL of Ca with channels

Ca inhibits opening of channels

11

absolute refractory period coincides with Na channel ""

inactivation

12

the "" of actin potentials is used to encode info in CNS

frequency

13

define accomodation in AP

membrane is continuously depolarized -> NaC progressively become inactivated -> accommodation -> results in AP frequency DOWN

14

define relative refractory period: Na channels and K channels

NaC: no longer inactivated

KC: open

15

elevation in extracellular K is called

hyper-KALEMIA

16

changes in EC (ion) can have dire consequence for brain

Na
(not K)

17

muscle weakness is a symptom of what two things

Hyper
-calcemia
-kalemia

18

what ion channel underlies plateau phase

Ca

19

trigger disease for abnormal neurofilament (pathway)

damaged axon leads to A-MYO-TROPHIC laterla sclerosis

20

defective keratin in skin causes what and why

this disease is called EPIDERMOLYSIS

causes blisters bc can't resist pressure

BULLOSA

21

PROGERIA (premature aging of child) is caused by what

mutation of LAMINA

22

diseases involving kinesin

anesthetic lidocaine INHIBITS kinesin movement in axons (same as stop forward transport of NT to nerve synapses)

Charcot MT neuropathy; interrupts transport of stuff

Retinitis pigmentosa

23

Na,K,Cl cotransporter is the target of what thing

diuretic called FURO-SE-MIDE

when inhibit, less water is taken back up and more water goes out in urine (diuresis)

24

Name two blistering diseases

#1 Epiderm Bullosa - mutation in keratin means blistering skin

#2 PEM-PHI-GOID - autoAb to hemidesmosome, causing blisters

25

topo iso merase are targets of what antibiotic

quino lone
(ex: cipro floxi cin)