Diseases - Cytogenetic abnormalities, Markers, and Other unique features Flashcards Preview

M2 Heme/Lymph > Diseases - Cytogenetic abnormalities, Markers, and Other unique features > Flashcards

Flashcards in Diseases - Cytogenetic abnormalities, Markers, and Other unique features Deck (32)
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1
Q

JAK2 kinase mutation

A

PV (100%)

MF (50%)

ET (50%)

2
Q

t(9,22)

A

CML

B-ALL

3
Q

-5q, -7q, +8

A

MDS

4
Q

t(15;17)

A

APL (AML)

5
Q

t(15;17), t(8;21), del(16)

11q23

A

AML: good prognosis

AML: bad prognosis

6
Q

Langherhans cell histiocytosis

A

CD1, langherin, BRAF

7
Q

markedly increased ferritin

A

HLH

8
Q

Reactive T-lymphocytes, polylconal

A

Inflammatory mononucleosis

9
Q

TdT

A

ALL (T and B)

10
Q

TdT with t(13;21) or hyperdiploidy

TdT with t(9;22), hypodipoloidy, or 11q23

A

ALL - good prognosis

ALL - bad prognosis

11
Q

CD5/19/23

A

CLL/SLL

12
Q

CLL/SLL ctyogenetics, name:

Good prognosis

Intermediate prognosis

Bad prognosis

A

13q, IGHV(+)

+12

11q, 17p, IGHV(-)

13
Q

TRAP, CD11a, CD22

A

Hairy cell leukemia

14
Q

CD4, CD25, HTLV-1

A

ATLL

15
Q

CD4, cerebriform nuclei

A

MF/SS

16
Q

CD8, eosinophilic granules

A

LGLL

17
Q

Mnemonic for end organ damage in MM

A

CRAB

hyperCalcemia

Renal damage

Anemia

Bone disease

18
Q

Highly localized Plasma cell neoplasm, may be associated with MM

A

Plasmacytoma

19
Q

IgM

A

LPL

20
Q

Like MM, but with no end-organ damage

A

MGUS

21
Q

CD10/19/20

A

Follicular lymphoma

Burkitt lymphoma

22
Q

CD19/20

A

MALToma (extranodal)

DLBCL

23
Q

T-helper cells, usually observed in adults, aggressive

A

Peripheral TCL

24
Q

CTLs, ALK rearrangements, seen primarily in children, aggressive

A

Anaplastic LCL

25
Q

NK, associated with EBV and South America or Asia, usually sinonasal, very aggressive/destructive

A

Extranodal NK/T

26
Q

CD20/45, popcorn cells

A

NLPHL

27
Q

CD15/30

A

Classic HL

28
Q

Reed-Sternberg cells

A

Classic HL

29
Q

“Soccer Ball” nucleus with “Ginger Snap” chromatin

A

CLL/SLL

30
Q

“Flower cells”

A

ATLL

31
Q

CD8, eosinophilic granules, associated with autoimmune disease (RA, etc)

A

LGLL

32
Q

t(11;18)

A

Extranodal marginal zone lymphoma (MALToma)