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Flashcards in Diuretics Deck (28):
1

Acts at PCT?

Acetazolamide, mannitol

2

Acts at thin descending limb?

Mannitol

3

Acts at thick ascending limb?

Loop

4

Acts at DCT?

Thiazide

5

Acts at CT?

K-sparing, ADH antagonists, mannitol

6

Decreases ICP and IOP?

Mannitol

7

AEs of mannitol?

Pulmonary edema!!!

8

Should not be given to CHF pts?

Mannitol

9

Can be used in drug OD?

Mannitol

10

Causes NaHCO3 diuresis?

Acetazolamide

11

Uses for acetazolamide?

Gluacoma, metabolic alkalosis, altitude sickness

12

Sulfa drugs?

Acetazolamie, loops, thiazides

13

Drugs causing acidemia?

Acetazolamide, K-sparing diuretics

14

Drugs causing alkalemia?

Loops, thiazides

15

MOA of loops?

Inhibits Na/K/2Cl cotransport abolishing hypertonicity of medulla

16

Drug that causes vasodilation on afferent arteriole due to PGE stimulation?

Loops

17

What do loops lose?

Ca, Na, K, Cl, H

18

Uses for loops?

CHF, nephrotic syndrome, HTN, hypercalcemia

19

AEs of loops?

Ototoxicity, hypokalemia/calcemia, dehydraiton, sulfa allergy, interstitial nephritis, gout

20

Drug may be used to tx HTN in gout pts or sulfa-allergy pts?

Ethacrynic acid

21

Phenoxyacetic acid derivative?

Ethacrynic acid

22

MOA of thiazides?

Inhibits NaCl reabsorption at DCT and decreases Ca excretion (binds Cl site on luminal surface)

23

Uses for thiazides?

HTN, nephrogenic DI, hypercalciuria

24

AEs of thiazides?

HyperGLUC, hyponatremia, diabetes

25

K-sparing diuretics?

Spironolactone, triamterene, amiloride, eplerenone (the K STAEys)

26

Uses for K-sparing diuretics?

Hyperaldosteronism (Conn's), K depletion, CHF

27

MOA of K-sparing diuretics?

1) Spironolactone and eplerenone are competitive aldosterone receptor blockers at cortical CT
2) Triamterene and amiloride block Na channels in cortical CT

28

AEs of K-sparing diuretics?

Hyperkalemia (can lead to arrhythmias), gynecomastia, antiandrogen effects