DNA Enveloped Viruses (Poxviridae) Flashcards Preview

Microbiology Block 1 > DNA Enveloped Viruses (Poxviridae) > Flashcards

Flashcards in DNA Enveloped Viruses (Poxviridae) Deck (26):
1

what is the biology of small pox?

 enveloped complex linear dsDNA

2

what is the biology of monkey pox?

 enveloped complex dsDNA

3

where does small pox replicate?

in the cytoplasm

4

what cells are primarily targeted by small pox?

respiratory mucosa

5

what is the course of the smallpox disease?

1) virus infects and multiples in respiratory mucosa cells

2) its carried to lymph nodes

3) primary viremia (carried in the blood)

4) virus reaches organs and causes skin rash

5) 2ry viremia occrus

6) dermal invasion occurs (characteristic vesicular rashes)

7) sepsis occurs 

6

what is essential to get rid of smallpox?

cell mediated immunity and humoral immunity 

7

why does a rash occur in smallpox?

because of viral replication followed by CTL attacking infected cells

8

how does the rash in small pox progress? (where does the rash start and where does it move to?)

it starts from the mouth and spreads to face, arms, legs, hands and feet. 

 

9

how does the rash in smallpox differ from the rash in varicella?

the smallpox rash is asynchronous  (papules will not be clustered)

10

is monkey pox more severe or milder than smallpox?

milder

11

pox virus (small and monkey) will have what type of inclusion bodies and in what part of the cell?

cytoplasm guarnieri inclusion bodies 

12

what is this?

Q image thumb

guarnieri bodies

13

what is vaccinia?

live attenuated virus vaccine

14

what is variolation?

vaccine that causes a wound

15

is there a vaccine for small pox?

yes

16

what 4 characteristics has helped eradicate smallpox?

1) humans are its only host

2) there is only 1 serotype

3) once you have immunity it will be lifelong

4) it is a transient infection 

5) the vaccine is inexpensive

17

smallpox vaccine is with what virus?

vaccinia, small pox cousin

18

what is the biology of molluscum contagiosum?

enveloped complex DNA virus

19

how does molluscum contagiosum spread?

it is contagious by close contact and fomites

20

who is most prone to get molluscum contagiosum?

children 

21

how harmful is molluscum contagiosum?

not harmful, benign

22

what is the clinical presentation of molluscum contagiosum?

Raised nodular to  wart-like tumors on the skin, clustered from 5-20, have a central caseous plug

23

what causes this?

Q image thumb

molluscum contagiosum

24

what causes this?

Q image thumb

molluscum contagiosum

25

how do you confirm a diagnosis of molluscum contagiosum?

you will see molluscum bodies histologically in the cytoplasm

26

what is this?

Q image thumb

molluscum bodies