DOACs Flashcards
What does warfarin antagonize?
Vit K
When is warfarin primarily used?
DVT, a fib, or mechanical heart valve
When is warfarin and heparin used together?
Treatment of MI, pulmonary embolus, post embolus CVA, and antiphospholipid syndrome
T or F warfarin reverses ischemic tissue damage
F
What is the peak time of warfarin
2-8 hours
What is the half life of warfarin
25-50 hours
When is the max effect of warfarin
48 hours
What lab level is most important to monitor
INR
When should you consider overlapping therapy with warfarin?
For 4-5 days after starting in urgent needs for anticoagulation
What are the severe effects of thrombosis on warfarin
Skin necrosis, purple toe syndrome
What patients have more polymorphisms for CYP2C9 affecting warfarin
Europeans
How often should PT INR be monitored in warfarin using patients
Two consecutive days, then several times weekly, then every 4 weeks
Which patient population have a lower target INR on warfarin
Bi leaflet aortic mechanical valves
How far apart should missed doses of dabigatran be taken
At least 6 hours apart from prior dose
What is the reversal agent if dabigatran
Idarucizumab
What is the reversal agent for factor Xa inhibitor
Andexant Alfa
Which factor 2a inhibitors shouldnt be used in pregnancy
Rivaroxaban and edoxaban
