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Flashcards in Dr Segars Starred Slides Deck (46)
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1

The designation of scheduled drugs determines what

Dispense quantity, refills allowed and a prescriptions life-span

2

1 kg = X number of pounds

2.2

3

W/v % = _____

W/v% = Grams in 100ml

4

Normal saline = what % NaCl

.9%

5

Parameters derived from the dose response curve

Emax
ED50

6

Graded response curves tell you what about the drug

How much is necessary

7

Quantal response curves tell you what

Yes or no - does the response occur or not and in how many individuals
Used to examine the frequency of a response within a large population

8

How to calculate therapeutic index

TD50/ED50

9

The range of doses of a drug or of its concentration in a bodily syste that provides for the safe and effective therapy

Therapeutic window

10

The lower the Kd

The higher the affinity of a drug for the receptor

11

T/f - antagonists have intrinsic activity

False - antagonists do not have intrinsic activity because they dont change the function of the receptor upon binding (intrinsic activity)

12

G protien family that activates Adenylyl cyclase and Src tyrosine kinase

Gs family

13

G protein family that inhibits AC but activates SRC

Gi family

14

G fall that activates phospholipase C

Gq

15

Voltage channel that is the target of local anesthetics, antiarrhythmic drugs and anti-epileptic drugs

Na channels

16

Target for inhalation genrreral anesthetics, IV anesthetics, ethanol and anti-anxiety benzodiazepine drugs

GABA-A receptors

17

Pancreatic adenocarcinoma associated with point mutations in what cells ignaling molecule

Ras

18

Verapamil targets what channel

L type calcium channels in heart - helps fix arrhythmias and angina

19

Topoisomerase type II inhibitor that induces expression of proapototic proteins in order to induce apoptosis in cancer cells

Etoposide

20

Na/K ATPase inhibitor

Digoxin

21

Aldosterone receptor antagonist

Spironolactone

22

Most important CYPs

CYP1A2
CYP2A6
CYP2D6
CYP2E1
CYP3A4

23

Most abundantly expressed and involved in expression of 50% of clinicaly used drugs (CYP)

CYP3A4

24

Individuals with a genetic defect in pseudocholinesterase metabolize what depolarizing neuromuscular blocking drug at 50% of the normal rate?

Succinylcholine - depolarizing neuromuscular blocking drug

25

Slow acetylators have trouble metabolizing what drugs

Isoniazid, hydralazine, caffeine and other similar amines

26

P450 inducers include

Phenytoin (anticonvulsant)
Chronic ethanol (CYP2E1)
Aromatic hydrocarbons
Rafampin (Tb)
Phenobarbital and other barbiturates

27

CYP inhibitor

Grapefruit juice

28

Allopurinol is given in combination with what drug in order to increase its efficacy? How does it work?

Mercaptopurine
Allopurinol inhibits xanthine oxidase, the metabolizer of mercaptopurine

29

Patients with this P450 enzyme (which metabolizes beta blockers, antidepressants, antipsychotics and opioid analgesics) convert codeine to morphine at an insufficient rate for pain relief

CYP2D6

30

Patients with this CYP mutation (a CYP that metabolizes PPIs, antidepressants, antiepileptics and antiplatelet drugs) are unable to metabolize clopidogrel to its active thiol metabolite and are at increased risk for acute coronary syndrome, stent thrombosis

CYP2C19
C for clopidogrel