Drug Dependence/Antidepressants Flashcards Preview

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Flashcards in Drug Dependence/Antidepressants Deck (25):
1

what is drug dependence

compulsive taking of drug

2

what is drug abuse?

illicit substance use
illicit use of legal substances
recurrent use/adverse consequences

3

what is habituation/adaptation in drug abuse?

rely on drug to avoid negative symptoms of withdrawal

4

reward pathways involve what NT system? where?

dopimanergic in nucleus accumbens

5

Amphetamines displace NA from vesicles and also 2 other NTs? which is it better at releasing?

5-HT
DA
better at releasing these two than NA

6

MDMA releases what? what does it do?

1. Dopamine/serotonin
2. stimulant/hallucinogenic

7

MDMA is tweaked version of what drug?

amphetamines

8

what happens the next time you take LSD?

need higher dose
cross-tolerance with other psychotomimetics

9

LSD activates what on 5-HT neurons?

autoreceptors in Raphe

10

Caffeine drug class?

Mathylxanthine

11

Caffeine blocks what?

adenosine antagonist
phosphdiesterase inhibitor

12

Alcohol can cause what at higher doses? does what to CNS?

causes Aggression
is a depressant

13

Alcohol inhibits what receptors? enhances what?

inhibits glutamate: NMDA
enhances GABA-A

14

what is abstinence syndrome?

eg. ethanol, feel so bad coming off, you just stay on

15

D9-THC is what? causes?

relaxation: no aggression
sharpened sensory awareness

16

D9-THC attaches to what receptors?

Cannabinoid receptors

17

2 kinds of cannabinoid receptors:

CB1: central
CB2: peripheral

18

antidepressants:1st, 2nd, 3rd generation?

1st: tricyclic/MAO inhibitors
2nd: SSRIs
3rd:novel MAO

19

Tricyclics did what? what was bad?

inhibit reuptake of NA and serotonin
poor selectivity

20

disadvantage of tricyclics

1. week to develop
2. narrow therapeutic window
3. gradual accumulation of side effects

21

MAO inhibitors did what?

increase 5-HT, NA, DA

22

What is the cheese reaction for MAO inhibitors?

in irreverisble MAOs: tyramine = hypertensive crisis

23

Reversible MAO inhibitors were better why?

less cheese reaction
MAOa selective

24

SSRIs did what? why was is good?

inhibit only serotonin reuptake
large therapeutic window

25

SSRI caution use in what population?

adolescents due to suicide