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Flashcards in Drug Interactions Deck (5)
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1
Q

Common P-gp Substrates

A

Anticoagulants: apixaban, edoxaban, rivaroxaban, dabigatran Cardiovasulcar drugs: carvedilol, digoxin, ranolazine Immunosupressants: cyclosporine, sirolimus, tacrolimus. HCV drugs: dasabuvir, paritaprevir, ombitasvir, simprevir, sofosbuvir Others: atazanavir, colchicine, dolutegravir, posaconazole, raltegravir, saxagliptin

2
Q

P-Gp Inducers

A

Carbamazapine, dexamethasone, phenobarbital, st johns wart, tipranavir

3
Q

Inhibitors of P-gp

A

Antiinfectives: clarithromycin, itraconazole, posaconazole CV drugs: amiodarone, carvedilol, dronedarone, conivaptan, diltiazem, quinidine, verampamil HIV: Conicistat, ritonavir, HCV: Daclatasvir, ledipasvir, paritaprevir, simeprevir Others: cyclosporines, filbanserin, ticagrelor

4
Q

Amiodarone interactions 2 major

A

warfarin (Ami is an inhibitor of CYP 2C9) and digoxin (Am inhibits P-gp decrease digoxin excretion) Decrease dose of warfarin b 30-50% if starting, then and start low when intiating warfarin)

5
Q

Digoxin and Loop Diuretics

A

Monitor electrolyte levels, K, Ca, Mg

Low or variable electrolyte concentrations increase arrythmia risks