Drug Metabolism Flashcards Preview

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Flashcards in Drug Metabolism Deck (4):
1

True or False.
Phase 1 reactions are also called functionalization reactions.
Phase 2 reactions are also called conjugation reactions.
Phase 2 reactions make drugs more polar and less lipid-soluble than the original molecule.
The most common Phase 2 reaction is glucoronidation.
Acetylation usually inactivated drugs.
The liver is the most important organ for drug metabolism.

True

2

Four examples of Phase 1 reactions

A HORDe of Phase 1 reactions
Hydrolysis
Oxidation
Reduction
Deamination

3

CYP450 enzyme which metabolizes the most drugs (#1 and #2)

#1: CYP3A4
#2: CYP2D6

4

True or False.
Anticonvulsants, if they have something to do with the CYP450, are inducers except for valproic acid.
SSRIs are CYP450 inhibitors.
Macrolides are CYP450 inhibitors except axithromycin, which do not have any effect on the CYP450.

True

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