Flashcards in Drug Metabolism Deck (4):
True or False.
Phase 1 reactions are also called functionalization reactions.
Phase 2 reactions are also called conjugation reactions.
Phase 2 reactions make drugs more polar and less lipid-soluble than the original molecule.
The most common Phase 2 reaction is glucoronidation.
Acetylation usually inactivated drugs.
The liver is the most important organ for drug metabolism.
Four examples of Phase 1 reactions
A HORDe of Phase 1 reactions
CYP450 enzyme which metabolizes the most drugs (#1 and #2)