Flashcards in Drug Targets - Cannabis and synthetic canaboids Deck (20):
What is the name of the cannabis plant?
What sort of cannabinoids are in cannabis plants?
20 carbon ringed structure
What are the endogenous cannabinoids?
listed in order found:
What is CB1?
What is the drug found in plants that acts on CB1?
What is THC?
THC is an agonist at CB1
What is potency?
The amount of drug required to produce EC50 (50% EMax), more potent = less drug.
What is efficacy?
The largest response able to be produced by the drug
What must be known to measure efficacy?
The signalling pathways
Describe THC at the receptor
THC is a weak (low potency) partial agonist at CB1
Are cannabinoids medicinal cannabis?
No, medicinal cannabis is just the plants. Cannabinoids are the drugs that act on the cannabinoids receptors.
Why should patients not use medicinal cannabis?
No quality control
Not regulated as to its processing
How many people have tried cannabis?
What are some suggested theraputic applications of cannabis?
Spinal cord injury (conditions with spasticity)
How do most medicines work?
They work by mimicking the endogenous ligand
How many unique drugs are there?
How many drug targets are there in the humans?
What is a cannabis based medicine?
Sativex (nasal spray), contains THC and CBD. Controlled dosage and used for spastic disorders when appropriate.
What has come into play to prevent people from using synthetic cannabinoids?
The psychoactive substances act,
summerized. Drugs must cause no more than low risk harm to users. must be proven.