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Flashcards in drug unique properties Deck (25)
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1
Q

Which two drugs cause histamine release

A

morphine and meperidine

2
Q

This drug has a long half life and is used to treat opioid addicts by removing them from the places and people that inspire them to use

A

methadone

3
Q

This drug can be subdermal implanted lasting 6 months

A

buprenorphine

4
Q

These two drugs have a lower abuse potential because of being a mixed agonist-antagonist

Resp depression?

A

buprenorphine butorphanol

yes

5
Q

this drug will cause resp depression, sedation, drowsiness, dysphoria, psychotomimetic effects, but has lower abuse potential
IV only

A

butorphanol

6
Q

This drug can revers opioid induced urinary retention and reverse fentanyl induced resp depression while maintaining some pain relief, but might make the patient crazy

A

nalbuphine

7
Q

This drug is long acting mu kappa delta antagonist,

can be taken orally, used to treat delayed resp depression, used to treat opioid addiction.

A

naltrexone

can cause severe withdrawals

8
Q

This drug is quintenary amine and is used to treat OIC

A

methylnaltrexone

9
Q

this drug is a GI specific opioid receptor antagonist
broken down in intestine, treats OIC
doesn’t cross BBB so doesn’t decrease pain relief

A

alvimpoan entereg

10
Q

this is the least lipophilic opioid

A

morphine

11
Q

structurally similar to atropine

A

meperidine

12
Q

this drug is metabolized into an excitatory metabolite that would be bad for a patient hepatic issues or on mao inhibitor
can cause serotonin syndrome(hypothermia, delirium, convulsion

A

meperidine

13
Q

10% unionized in plasma

A

fentanyl

14
Q

highly protein bound opioid, toxic for elderly

A

fentanyl

15
Q

Renal failure patients would want to avoid what two opioid drugs

A

morphine meperidine

16
Q

this drug induces uterine contraction

A

carboprost

hemabate

17
Q

what drug is most likely to give you a stomach ulcer

A

ketorolac

18
Q

this anti inflammatory drug would have a liver toxicity concern

A

celecoxib

19
Q

water soluble prodrug

A

parecoxib

20
Q

piperidines

5

A
meperidine
fentanyl 
sufentanil
alfentanil 
remifentanil
21
Q

Diphenylheptanes

1

A

methadone

22
Q

tramadol is a ?

A

racemic mixture of
r isomer partial mu agonist
s isomer blocks NE and serotonin uptake

23
Q

tramadol cause cause resp depression T/F

A

t

24
Q

eluxadoline is used for _____ and activiates______causing what 5 things

A
  • diarrhea predominant IBS
  • mu receptor on myenteric and submucosal neurons
    1. reduce GI motility
    2. reduced forward peristalsis
    3. decreased GI mucus/juice secretion
    4. increased circular contractions
    5. increased fluid absorption
25
Q

eluxadoline has a great or poor bioavailability

A

poor oral availability