drugs Flashcards by Elizabeth Malik

Q

Cyclosporine

A

CYP3A immuno-suppressant. Stops T-cells from growing

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Q

Felodipine

A

CYP3A Calcium-channel blocker

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Q

Grapefruit juice

A

CYP3A inhibitor

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Q

Ketoconazole

A

CYP3A inhibitor, Azole antifungal agent

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Q

Rifampin

A

CYP3A Inducer, a Rifamycin

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Q

Amitriptyline

A

CYP2D6 tricyclic antidepressant

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Q

Clomipramine

A

CYP2D6 tricyclic antidepressant

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Q

Desipramine

A

CYP2D6 tricyclic antidepressant

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Q

Imipramine

A

CYP2D6 tricyclic antidepressant

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Q

Nortryptyline

A

CYP2D6 tricyclic antidepressant

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Q

Codeine

A

CYP2D6 opioid, can be converted to morphine

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Q

Quinidine

A

CYP2D6 Inhibitor

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Q

CYP2D6

A

CYP sub-family that usually activates drugs

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Q

Fluoxetine

A

CYP2D6 inhibitor

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Q

Paroxetine

A

CYP2D6 inhibitor

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Q

Warfarin

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A

aka Coumadin, CYP2C19 substrate, anti-coagulant. Inhibits VKORC1 from reducing Vit K

Q

Isoniazid

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A

N-acetyltransferase (NAT) enzyme, used to treat TB

Q

6-mercaptopurine

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A

Destabilizes thiopurine methyltransferase (TMPT) to treat ALL (leukemia) or IBD

Q

6-thioguanine

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A

Destabilizes thiopurine methyltransferase (TMPT) to treat ALL (leukemia) or IBD

Q

Sulfonamide

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A

treats G6PD deficient patients

Q

Dapsone

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A

treats G6PD deficient patients

Q

Azanthioprine

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A

Thioprine methytransferase inhibitor, ALL (leukemia) cure by myelosuppression

Q

Imiglucerase

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A

aka Cerazyme. Gaucher disease drug that is β-glucocerebrosidase analog

Q

Velaglucerase (VPRIV)

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A

Gaucher disease drug that is hydrolytic lysosomal glucocerebrosidase

Taliglucerase alfa

Gaucher disease drug that is hydrolytic lysosomal glucocerebrosidase from carrots

Miglustat

aka Zavesca Gaucher disease drug that inhibits glucosylceramide synthase (substrate reduct. therapy)

Gleevec

tyrosine kinase inhibitor to treat CML (leukemia)