DRUGS

Question 1

Prednisone / Steroids

Answer 1

Inhibit inflammation, reduce TGF-β, suppress immune response & Autoimmune diseases, reduce inflammation, slow fibrosis

Question 2

Nintedanib

Answer 2

Tyrosine kinase inhibitor (VEGFR, FGFR, PDGFR), Idiopathic Pulmonary Fibrosis (IPF)

Question 3

Pirfenidone

Answer 3

Inhibits TGF-β and collagen synthesis, Idiopathic Pulmonary Fibrosis (IPF)

Question 4

Dasatinib + Quercetin

Answer 4

Senolytics – clear senescent cells, Pulmonary fibrosis, ageing-related diseases

Question 5

Rituximab

Answer 5

Anti-CD20 B-cell depleting antibody, SSc-ILD, autoimmune ILD, rheumatoid arthritis

Question 6

Imatinib (Gleevec)

Answer 6

Inhibits BCR-Abl, c-Kit, PDGFRα, CML, GIST

Question 7

Dasatinib

Answer 7

Broader TKI (BCR-Abl, Src), CML, imatinib-resistant cases

Question 8

Ponatinib

Answer 8

Effective against T315I mutation in BCR-Abl, Resistant CML

Question 9

Trastuzumab (Herceptin)

Answer 9

HER2 monoclonal antibody, HER2+ breast cancer

Question 10

Pertuzumab

Answer 10

HER2 antibody targeting a different epitope, HER2+ breast cancer

Question 11

T-DM1 (Trastuzumab-emtansine)

Answer 11

Antibody-drug conjugate (trastuzumab + chemo), HER2+ breast cancer

Question 12

Cetuximab

Answer 12

EGFR monoclonal antibody, Colorectal, head and neck cancers

Question 13

Bevacizumab

Answer 13

Anti-VEGF antibody, Cancer (e.g., colorectal, lung), macular degeneration

Question 14

Fluoxetine (Prozac)

Answer 14

SSRI – blocks serotonin reuptake, Depression, anxiety

Question 15

Ketamine

Answer 15

NMDA receptor blocker, Anaesthesia, treatment-resistant depression

Question 16

Perampanel

Answer 16

AMPA receptor antagonist, Epilepsy (anti-seizure)

Question 17

Tricyclic Antidepressants

Answer 17

Inhibit monoamine reuptake, also affect glycine transport, Depression, neuropathic pain

Question 18

Haloperidol, Clozapine

Answer 18

Antipsychotics (non-specific inhibitory effect on Glyts), Schizophrenia, psychosis

Question 19

Saquinavir

Answer 19

HIV protease inhibitor, HIV/AIDS

Question 20

Darunavir

Answer 20

Improved HIV protease inhibitor, HIV/AIDS (resistant strains)

Question 21

Cephalosporins (e.g., Cefalexin)

Answer 21

β-lactam antibiotics inhibiting cell wall synthesis, Bacterial infections

Question 22

7-ACA (7-Aminocephalosporanic acid)

Answer 22

Precursor for semisynthetic cephalosporins, Intermediate for antibiotic production

Question 23

CAR-T for FAP

Answer 23

Targets fibroblast activation protein, Experimental anti-fibrotic therapy

Question 24

Stem Cell Therapy

Answer 24

Regenerates tissue, reduces inflammation, IPF, autoimmune diseases

Question 25

TRV130

Answer 25

The binding of morphine and TRV130 stabilize different µ-opioid receptor states. Only analgesia

Question 25

Maraviroc

Answer 25

Allosteric Modulator that decreases affinity of gp120 on HIV-1 for CCR5 and decreases viral entry

Question 26

DAMGO

Answer 26

Treat morphine tolerance by binding to monomer (dragging) internalising opioid receptor. Can be resensitised later. (homo)

Question 27

DMX-200

Answer 27

Treatment of the heteromerization of AT1 and CCR2 in chronic kidney disease. AT1 and CCR2 can form a complex that worsens inflammation and kidney damage.

Question 28

Cocaine

Answer 28

* binds to DAT and inhibits DA reuptake * decrease the amount of GABA neuron activity, which disinhibits DA neurons

Question 29

Amphetamine

Answer 29

reverses the direction of DAT and alters DA reuptake