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Flashcards in Drugs Deck (13)
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1
Q

Dexamethasone

A
analog of cortisol
anti-inflammatory and immunosuppressant
super potent
bacterial meningitis
RA
2
Q

Prednisone

A

prodrug–> activated in liver

3
Q

Betamethasone

A

cortisol analog

topical

4
Q

Methotreaxate (MTX)

A

DMARD- small molecule
RA, Crohns, Lupus
immunosuppressive effect (suppresses T cell activation and B cell proliferation)

5
Q

Leflunomide (ARAVA)

A

DMARD- small molecule
blocks proliferation of activated lymphocytes
serious side effects on Liver

6
Q

Infliximab (REMICADE)

A

TNF DMARD
binds to both soluble and membrane-bound TNF alpha
induces apoptosis of lymphocytes
used in RA, Crohns, and AS

given in combination with Methatrexate

7
Q

Etanercept (Enbrel)

A

TNF DMARD
binds soluble TNF
fusion protein (human)
treat RA, Crohns, AS

8
Q

Adalimumab (HUMIRA)

A
TNF DMARD
binds soluble TNF (acts like sponge)
monoclonal antibody
down regulates macrophage and T cell function
RA and Crohn's
9
Q

Tocilizumab

A

biologic DMARD
monoclonal antibody against IL-6 receptor
used if TNFs are not tolerated

10
Q

Anakinra (KINERET)

A

biologic DMARD
monoclonal antibody against IL-1 receptor
used if TNF don’t work

11
Q

Tofacitinib (Xeljanz)

A

DMARD
RA treatment when Methotrexate doesn’t work
Blocks JAK/STAT pathway

ORAL PILLS
usual side effects

12
Q

Abatacept

A

biologic DMARD

inhibit T cells by interfering with CD80 and CD28

13
Q

Eculizumab

A

humanized monoclonal antibody that blocks C5 from being cleaved–> prevents MAC

patients are going to be at risk for encapsulated bacterial infections such as Neisseria