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Flashcards in Drugs Deck (19):
1

What class of drug is abciximab?

Glycoprotein IIb/IIIa receptor

2

What class of drug is eptifibatide?

Glycoprotein IIb/IIIa receptor

3

What class of drug is tirofiban?

Glycoprotein IIb/IIIa receptor

4

Side effect of clopidogrel?

Skin rash
Other SEs: diarrhoea, abdominal pain, dyspepsia

5

Side effect of aspirin?

Can precepitate bronchospasm (up to 20% of asthmatic adults)
Gastric side effects: nausea to major GI bleeds

6

Contraindications to ACEi?

Aortic/mitral valve stenosis
Angioedema
Hypersensitivity to ACEis
Bilateral renal artery stenosis
Pregnancy

7

ACEi monitoring?

Baseline BP, urea and electrolytes before starting.
Check BP and U&E's within 2 weeks of starting/changing dose
Then check BP and U&E's annually

8

Side effects of ACEi?

First-dose hypotension (avoid excessive diuretics prior to initiation)
Dry cough
Andioedema (rare but potentially life-threatening adverse effect)
Rash

9

Contraindications to beta-blockers?

Asthma
Second or third degree heart block
Severe peripheral vascular disease
Patients on verapamil

10

Adverse effects of CCBs?

Bradycardia
Hypotension
Flushing (gets better with time)
GI disturbance - may make constipation worse
Ankle oedema
Gingival hyperplasia

11

Side effects of statins?

Gi disturbance
Insomnia
Muscle aches and pains, myopathy

12

Adverse effects of nitrates?

Hypotension
Headache

13

How does nicorandil work?

Potassium channel activator

14

Adverse effects of potassium channel activators?

Headache
Dizziness and hypotension
Fludhing
ULCERATION - GI ulceration, skin ulceration, ulceration of the mucosal membranes

15

Adverse effects of ivabradine

Visual symptoms (luminous phenomena, blurred vision)
Bradycardia/ AV 1st degree block
Headache
Dizziness
GI disturbances

16

Side effect of hydralazine

Drug-induced lupus

17

Beta-blockers that improve survival in heart failure?

Bisoprolol, carvedilol, nebivolol

18

When would you give digoxin in heart failure?

If symptoms persist despite ACEi, betablocker and aldosterone antagonist
-particularly useful if patient has AF as well!!

19

Vaccines to offer in heart failure

-once off pneumococcal
-annual flu vaccine