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Flashcards in DRUGS Deck (18)
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1
Q

Which drugs affect dopamine inactivation?

A
  • MOAb inhibitors
  • COMT inhibitors
  • antimuscarinic drugs
2
Q

MOAb inhibitors - examples of mechanism of action

A

Selegilline
Rasagiine
- stop dopamine being broken down in pre-synaptic neurons (dopamine to DOPAC)

3
Q

COMT inhibitors

A

Entacapone
Tolcapone
- stop dopamine degradation from DOPAC to homovanillic acid
- may also help alleviate L-Dopa side effects so can use for loner

4
Q

Antimuscarinics

A

aAntagonists of muscarinic acetylcholine receptors, increasing dopamine release and inhibiting re-uptake

  • benzhexol
  • benztropine
5
Q

Which drugs affect dopamine storage?

A
  • reserpine
  • tetrabenazine
  • amantadine
6
Q

Amantadine

A

Increases release of dopamine from monoaminergic terminals through inhibiting amine uptake, MOA activity

7
Q

Which drugs decrease release of dopamine?

A

Reserpine
Tetrabenazine
- inhibit vesicular storage of dopamine by irreversibly inhibiting VMAT2 (vesicular monoamine transporter)

8
Q

Which drugs affect dopamine synthesis?

A

Madopar
L-Dopa
Alpha methyl-p-tyrosine

9
Q

Alpha methyl-p-tyrosine

A

Competitive inhibitory of dopamine

- inhibits tyrosine hydroxylase so synthesis rate limiting step (tyrosine-> DOPA)

10
Q

Madopar

A

L-DOPA + benserazide (peripheral decarboxylase inhibitor) preventing L-DOPA to dopamine conversion outside of the BBB as benserazide cannot get through the BBB

11
Q

Which drugs are post synaptic dopamine receptor agonists?

A
Pergolide
Quinpirole
Bromocriptine
Apomorphine
Rotigotine
12
Q

Pergolide and quinpirole

A

D1 and D2 non selective agonists

13
Q

Bromocriptine

A

High D2 affinity, dopamine agonist

14
Q

Apomorphine

A

Non selective dopamine agonist potent emetic, infusion

15
Q

Rotigotine

A

Non-selective dopamine agonist transdermal patch

16
Q

Which drugs are post synaptic dopamine receptor antagonists?

A
Chlorpromazine
Haloperidol
Spiperone
Sulrpide
Clozapine

(used to treat schizophrenia, high D2 affinity)

17
Q

Anticholinergics

A

As loss of dopamine = increased activity

-orphenadrine and procyclidine

18
Q

L-DOPA

A

Levodopa

Carbidopa