Albuterol
USE: DOC for prompt asthma attack
MOA: SABA, stabilizes mast cell membranes
SE: Skeletal muscle tremor and cardiac stimulation
Salmeterol
USE: Adjunctive therapy
MOA: LABA
SE: Skeletal muscle tremor and cardiac stimulation
Fluticasone
USE:
1. inhibit inflammation
2. decrease mucous production and hypesecretion
3. Increase B2 receptor levels
MOA: Act on cytoplasmic glucocorticoid receptors to stimulate protein synthesis
SE: THRUSH (with inhaled form)
Tiotropium (“trops” like atropine)
USE: COPD
MOA: LAMA (long acting muscarinic antagonist)
Cromolyn
USE: Anti-inflamatory
MOA: Inhibit pulmonary mast cell degranulation
Montelukast
USE: Leukotriene Antagonist
MOA: Blocking Leukotriene receptor- Cys-LT1
SE: Headache
Zileuton
USE: Leukotriene antagonist, alternative to inhaled steroids, children, orally, allergies
MOA: Blocks 5-lipoxgenase enzyme (synthesis)
Bupropion (zyban)
USE: Smoking cessation, anti-depressant
MOA: Blocks NE and Dopamine reuptake
SE: suicide
Varenciline (chantix)
USE: Smoking Cessation
MOA: Nicotinic receptor partial agonist
SE: suicide
What is the top strategy for COPD?
Bronchodilators: SABA (as needed) and LAMA (daily prevention)
Phenylephrine
USE: Acute and chronic Rhinitis (decongestant, decrease mucus production)
MOA: Stimulate alpha 1 receptors
Dextromethorphan
USE: Cough
MOA:
SE: CNS depression
Benzonatate
Cough suppressants
Guaifenesin
Expectorant that decreases adhesiveness and surface tension
Mesalamine
USE: Crohn’s Disease!
MOA: Works anywhere throughout GI tract
Sulfasalazine
USE: ONLY Ulcerative Colitis!
MOA: broken down in colon so only acitve after the colon (and Crohn’s could be before that)
Infliximab, Natalizumab
Anti-TNF alpha drugs
Natalizumab= alpha 4-integrin
-blocks leukocyte migration to sites of inflammation
Ondansetron (“setrons”)
5HT3 receptor blocker
dance you take a 5H3T
Promethazine
D2 receptor blocker
Hes pretty much a Pro, he went D2
Diphenhydramine
1st gen H1 blocker
Aprepitant
Cancer Chemotherapy pts
NK1 antagonist
Substance P