Drugs by Effect

Question 1

enhances topical absorption, may be toxic

Answer 1

DMSO

Question 2

treats GERD in stomach by inhibiting P450

Answer 2

Cimetidine

Question 3

barbituate, induces CYP3A4,5,7

Answer 3

phenobarbital

Question 4

Co-penicillin drug, decreases excretion via urine

Answer 4

probenecid

Question 5

Muscarinic antagonist, Gi bladder atony,

Answer 5

bethanechol

Question 6

muscarinic agonist, treats glaucoma

Answer 6

muscarine

Question 7

muscarinic agonist, treats dry mouth and glaucoma

Answer 7

pilocarpine

Question 8

nicotinic agonist, CNS, both relaxing and stimulating

Answer 8

nicotine

Question 9

anticholinesterases, work GI, increase Ach, PS effects

Answer 9

physostigmine (for atropine OD), neostigmine

Question 10

muscarinic antagonist, treats bradycardia, dilates pupils

Answer 10

atropine

Question 11

muscarinic antagonist, vestibular stimulation, locally for motion sickness

Answer 11

scopolamine

Question 12

nicotinic antagonist, treats hypertension by lowering autonomic ganglia’s predominant input

Answer 12

hexamethonium

Question 13

nonselective agonist, heart, lungs, vasculature (cardiac arrest, anaphylaxis)

Answer 13

epinephrine

Question 14

agonist of alpha1, beta1, heart and vasculature, treats hypotension

Answer 14

norepinephrine

Question 15

Alpha 1 agonist, treats hypotension

Answer 15

phenylephrine

Question 16

Alpha 2 agonist, decreases NE secretion at synapse, treats hypertention

Answer 16

clonidine

Question 17

Beta1 and 2 agonist, heart, treats hypotension

Answer 17

isoproterenol

Question 18

Beta 2 agonist, treats asthma

Answer 18

terbutaline, albuterol

Question 19

indirect sympthomimetic psychostimulant

Answer 19

cocaine, amphetamine, ephedrine

Question 20

indirect sympthomimetic antidepressant

Answer 20

imipramine

Question 21

hypertensive crisis when ______ causes increase in NE

Answer 21

tyramines can’t be broken down by MAOs (MAO inhibition)

Question 22

alpha blocker, noncompetitive, treats hypertension

Answer 22

phenoxybenzamine,

Question 23

alpha blocker, competitive, treats hypertension

Answer 23

phentolamine

Question 24

Alpha 1 blocker, treats hypertension

Answer 24

prazonsin

Question 25

Alpha 2 blocker, treats erectile dysfunction

Answer 25

yohimbine

Question 26

nonspecific beta blockers: reduce cardiac output, bronchoconstriction

Answer 26

propranolol, pindolol, timolol

Question 27

Beta 1 blocker, treats hypertension

Answer 27

atenolol

Question 28

Beta 1 & Alpha 1 blocker, lowers cardiac output and vasodilates

Answer 28

carvedilol

Question 29

false transmitter for NE, alpha 2 agonist (treats hypertension)

Answer 29

methyldopa

Question 30

lowers NE uptake by VMAT, treats hypertension

Answer 30

reserpine

Question 31

Lead and Ca chelator

Answer 31

EDTA

Question 32

lead chelator, not Ca, fewer side effects than EDTA

Answer 32

Calcium Disodium EDTA

Question 33

Pb, As, Hg, Ag chelator

Answer 33

Dimercaprol (BAL)

Question 34

Pb and Cu chelator

Answer 34

Penicillamine (Cuprimine)

Question 35

Pb chelator with multistep therapy to combat rebound

Answer 35

DMSA (2,3-dimercaptosuccinic acid)

Question 36

Fe chelator, treats hemochromatosis

Answer 36

deferoxamine

Question 37

treat allergies by blocking peripheral H1 receptors + CNS

Answer 37

diphenhydramine (benadryl), dimenhydrinate (dramamine), Chlorpheniramine (chlortrimeton), Cyclizine (Marezine), Meclizine (Antivert, Bonine), Promethazine (Phenergan)

Question 38

treat allergies by blocking peripheral H1 receptors (not in CNS)

Answer 38

Loratadine, Desloratadine, fexofenide, Cetirizine (Claritin, Clarinex, Allegra, Zyrtec)

Question 39

treat stomach acid but lowering gastric acid secretion (H2)

Answer 39

Cimetidine, Ranitidine, Famotidine (Tagamet, Zantac, Pepcid)

Question 40

COX path: vasodilation, lowers platelet aggregation, lows gastric acid, increases mucus in stomach

Answer 40

PGI2

Question 41

COX path: induces labor, increases uterine contraction

Answer 41

PGE2 (causes fever, pain) PGF2alpha, Misoprostol

Question 42

COX path: increases platelets (TXB2 is product)

Answer 42

TXA2

Question 43

COX and Lipox pathway: anti-inflammation through lowered formation of free arachadonic acid

Answer 43

corticosteroids

Question 44

Lipoxy path: BLT1 receptor, attracts neutrophils

Answer 44

LTB4

Question 45

Lipoxy path: cycLT2 receptor, causes edema

Answer 45

LTC4

Question 46

Lipoxy path: cysLT1 receptor, causes bronchoconstriction

Answer 46

LTD4

Question 47

Lipoxy path: decreases 5-lipoxygenase, treats asthma, allergies

Answer 47

Zileuton (Zyflo)

Question 48

analgesic, antipyretic, anti-inflammatory: irreversibly inhibits COX, inhibits TXA at low doses

Answer 48

aspirin

Question 49

analgesic, antipyretic, anti-inflammatory: weakly inhibits COX, less GI irritation

Answer 49

salsalate

Question 50

analgesic, antipyretic, anti-inflammatory: reversibly inhibits COX1,2, NF-kb

Answer 50

sodium salicylate

Question 51

analgesic, antipyretic, anti-inflammatory: competitively binds COX

Answer 51

diflusinal

Question 52

reversibly inhibits COX, treat inflammatory bowel disease

Answer 52

mesalamine, sulfasalazine

Question 53

antipyretic, analgesic. Induces M404 in CNS, which reduces COX

Answer 53

acetaminophen (tylenol) not a good anti-inflammatory

Question 54

antidote for acetominophen OD, repletes glutathione levels in liver

Answer 54

N-acetylcysteine

Question 55

Nonselective COX inhibitors: analgesics for arthritis (joints)

Answer 55

Indomethacin/Indocin (CNS side effects), Sulindac

Question 56

Nonselective COX inhibitors: analgesics for arthritis, dysmenorrhea (joints and muscles)

Answer 56

Ibuprofen, naproxen

Question 57

Nonselective COX inhibitor: post-surgical

Answer 57

ketorolac (Toradol)

Question 58

COX-2 selective inhibtors: no GI side effects, but increased TXA causes cardiac effects

Answer 58

Celecoxib (Celebrex), Rofecoxib (Vioxx)