Drugs For Anemia And Hematopoeitic Growth Factors Flashcards Preview

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Flashcards in Drugs For Anemia And Hematopoeitic Growth Factors Deck (22):
0

Increased or Decreased in Iron Deficiency Anemia?
Iron
Ferritin
TIBC

Decreased
Decreased
Increased

1

Deficiency in _______ or _______ can cause megaloblastic anemia

Vitamin B12 or folic acid

2

Heavy metal chelator
Drug for acute Iron Toxicity
SE: ARDS, neurotoxicity, susceptibility to infections

Deferoxamine, Chelator

3

Tx for IDA

Ferrous Sulfate

4

Most common type of megaloblastic anemia

Pernicious anemia (defect in IF synthesis)

5

Drug with most amount of iron concentration

Ferrous Fumarate

5

Acute overdose of ferrous sulfate causes

Necrotizing gastroenteritis

7

Chronic iron overload can cause

Hemochromatosis

8

Triad of hemochromatosis
Occurs in pxs with abnormal iron absorption or frequent transfusions

Cirrhosis
DM
Hyperpigmentation

9

Tx for hemochromatosis

Phlebotomy
Chronic Deferoxamine (IV) or Deferasirox (IM)

10

Co factor in transfer of 1 carbon units, necessary step for DNA synthesis

Drug?

Vit B12

11

____________ deficiency causes neurologic effects

Vit B12

NOT FOLIC ACID

12

Neurologic effect of Vit B12 deficiency

Ataxic gait
Impaired position and vibratory sense
Spasticity

13

__________ deficiency: RBC production slows down

Vit B12

14

Hematoietic Growth Factor
Cofactor required to convert homocysteine to methionine, and metabolize methylmalonyl CoA
Drug for Vit B12 deficiency, megaloblastic anemia

Cyanocobalamin
(Hydroxocobalamin)

15

Required for normal DNA synthesis
Deficiency can cause NTD (Spina Bifida)

Drug?

Folic Acid

16

Area of the GIT where Folic Acid is absorbed

Proximal jejunum

17

Hematopoietic Growth Factor
Essential donor of methyl groups for synthesis of AA, purines and deoxynucleotide
Drug for megaloblastic anemia, prevention of coronary artery disease, prevention of NTD

Folic Acid (synthetic)
Folate (natural)
(Folacin, Folinic Acid)

18

Agonist of Erythropoeitin receptors expressed by red cell progenitors
Drug associated with CKD
SE: pure red cell aplasia
HgB should be maintained <12g/dl
Prohibited as performance enhancing drug

Epoetin Alfa

LAHAT NG MAY EPO

19

Myeloid growth factor
Accelerates neutrophil recovery and reduces incidence of infection
Drug for neutropenia associated with chemotherapy
SE: arthralgia, fever, edema

Granulocyte Colony Stimulating Factor (G-CSF)

LAHAT NG MAY -STIM

21

Treatment of neutropenia and agranulocytosis

Filgrastim

22

Megakaryocyte growth factor
Activate IL-11 receptors
Drug for prevention of chemotherapy induced thrombocytopenia
SE: pleural effusion, transient atrial arrhythmia

Oprelvekin
(Thrombopoietin)