Drugs for Heart Failure Flashcards Preview

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Flashcards in Drugs for Heart Failure Deck (32):
1

Type of failure where the weakened heart muscle can't squeeze as well and less blood is pumped out of ventricles

Systolic heart failure

2

Type of heart failure where the heart muscle is stiff/can't relax and less blood fills the ventricles

Diastolic heart failure

3

Heart Failure class I

mild-no limitation of activity

4

Heart failure Class II

mild-slight limitation, ordinary physical activity results in fatigue, palpitation, or dyspnoea

5

Heart Failure Class III

Moderate-Marked limitation, less than ordinary activity causes fatigue, palpitation.dyspnoae

6

Class IV heart failure

Severe-unable to do any physical activity without discomfort, uncomfortable at rest.

7

Depolarization of the cardiac myocyte leads to operning of the

voltage gated Ca++ channels

8

Ca influx activates___?

Ryanodine receptors

9

____ drugs alter the force or energy of muscular contractions.

Inotropic

10

Negative inotropes ____ the force

weaken

11

Postive Inotropes ____ the force

Increase

12

_____ drugs may change the heart rate by affecting the nerves controlling the heart or by changing the rhythm produced by the sinoatrial node.

Chronotropic

13

____ chronotropes increase heart rate

Positive

14

____ chronotropes decrease heart rate

Negative

15

Cardiac Glycosides (digoxin), B adrenergic receptor agonists, bipyridines are all examples of

Positive Inotropic drugs

16

B adrenergic receptor blockers, diuretics, angiotensin converting enzymes inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, vasoldilators are all ____

Drugs with positive inotropic effects used to treat heart failure

17

Mechanism of action for Digoxin

Blocks Na+/K+ ATTPase- internal sodium increases which slows the Na/Ca exchanger, slowing removal of Ca.

18

Domutamine is a

B1-adrenergic receptor agonist

19

T/F All B blockers are effective for B-adrenergic receptor antagonists to treat heart failure

False-Bucindolol is not effective

20

Thiazide is a

diuretic

21

91% of patients with heart disease also have

periodontitis

22

angina is caused from

the heart not receiving enough oxygen from the blood

23

Nitrates/nitrites, B-adrenergic receptor blockers, Ca channel blockers, aspirin, antiplatelet, and anticoagulant drugs, ranolazine are all drugs used to treat ____

angina

24

All organic nitrates/nitrites are prodrugs that spontaneously produce

Nitric oxide

25

Nitric oxide ultimately activates ____

Protein Kinase G

26

Protein Kinase G activation leads to

smooth muscle relaxation

27

adverse effects of nitrates/nitrites

Headache, hypotention, facial flushing and tachycardia

28

Beta blockers cause

Decreased HR, O2 demand, contractility

29

Ca channel blockers cause

Decreased HR, O2 demand, contractility,

30

Nitrates, Ca blockers, Beta blockers are all used to treat

Angina

31

Nitrates and Ca blockers are

Vasodilators

32

Ca blockers and Beta blockers are

Cardiac depressants