Flashcards in Drugs for Osteoarthritis, Joint Disease - Fitz Deck (13)
Easy drug for analgesia (PAIN CONTROL) in osteoarthritis?
Oral drugs for ANTI-INFLAMMATION in osteoarthritis?
IF NSAIDs FAIL, drug for anti-inflammation of joint?
Triamcinolone (steroid injection)
Represses COX-2 transcription and translation, thus can't be turned on
Patient presents to ER w/ emesis, jaundice, altered mental status. Recently been depressed/despondent. Has severe osteoarthritis.
What is found in blood?
What does this molecule do?
Acetaminophen OD (hepatic centrolobular necrosis)
Elevated NAPQI (metabolite)
Binds glutathione, uses it up, then does damage in liver
How long does it take for acetaminophen toxicity to see full toxicity/toxic effects?
Will first see symptoms when?
Within the 1st day
Treatment for acetaminophen toxicity
Mild OA, minimal inflammation...drug?
Takes it for 2 weeks, only gets worse...drug?
Giving an NSAID for OA. Be cautious of what?
- GI risk profile
- CV risk profile
- Hypersensitivity (sulfa)
Best NSAIDs to give for short term OA relief (4)
Best NSAIDs to give for longer term OA relief - 1x per day (2)
Can multiple NSAIDs be taken at the same time? Why?
NO - will compete for absorption and increase risk for GI bleeding/ulcer
Way to avoid GI bleeding/ulcer risk when taking NSAID?
Taking w/ Misoprostol (PGE1) or PPI (Omeprazole)
Narcotics for pain
Morphine, Codeine, Tramadol
Mu-receptor agonists (analgesia)
Pupil constriction, respiratory depression