Drugs of Dependence and Antidepressants Flashcards Preview

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Flashcards in Drugs of Dependence and Antidepressants Deck (17):
1

What is drug dependence?

Addiction
Drug use becomes compulsive and takes precedence over other needs

2

What is drug abuse?

Use of illicit substances (or illicit use of illegal ones) characterised by recurrent & chronically significant adverse consequences

3

Important site of the reward pathway...1... mediated by the release of ...2..

1 Nucleus Accumbens
2 Dopamine

4

People who become addicted to drugs tend to have lower levels of ----- in the nucleus accumbens to start with

Dopamine

5

What are some examples of 1st generation antidepressants?

Tryciclic AntiD
MAO inh

6

Tryciclic AntiD mechanism of action

inhibit neuronal uptake of NA and serotonin
narrow therapeutic window, side effects come first

7

MAO inh mechanism of action

increases levels of NA, Dopamine and serotonin by inhibiting the enzyme that breaks them down

8

2 generation of antidepressants include

Selective Serotonin Uptake Inhibitors (SSRI)
Selective Serotonin/Noradrenaline Uptake Inhibitors (SSNRI)

9

Caffeine belongs to the drug group...

Methylxanthine

10

MDMA (ecstacy) prolonged use causes

death of hyppocampal neurons

11

Site of action for LSD

5HT2 R

12

Why does LSD tend to be less addictive?

BAd trips

13

is alcohol a depressant or stimulant? why?

Depressant, inhibits Ca+2 channels in the CNS. inhibits glutamate R and enhances GABA activity

14

Active compound found in Marijuana

D9 THC

15

D9 THC mechanism of action?

acts on G protein coupled receptors blocking the activity of adenylate cyclase (inhibits the inhibition of inhibitory pathway ---> more inhibition)

16

NMDA causes the release of

Serotonin and Dopamine

17

LSD use causes the...

Confuses sensory modalities, hallucinations