Drugs Used in Coagulation Disorders Flashcards Preview

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Flashcards in Drugs Used in Coagulation Disorders Deck (22):
1

Factors promoting platelet aggregation: (2)
Factors that prevent platelet aggregation: (3)

Serotonin
Thromboxane A2

cAMP
Prostacyclin (PGI2)
PGE1

2

Names of clotting factors
I --
Ia --
II --
IIa --

I -- fibrinogen
Ia -- fibrin
II -- prothrombin
IIa -- thrombin

3

Drug associated with Reye syndrome (liver failure, encephalopathy) especially in children given aspirin after a viral infection

Aspirin

4

Aspirin
Toxic dose: _____________
Lethal dose: _____________

150 mg/kg
500 mg/kg

5

Expected acid-base abnormality in salicylate poisoning

Respiratory alkalosis with HAGMA (adults)
HAGMA (children)

6

Antiplatelet drug; Gp2b3a inhibitor (blocks final common pathway of platelet aggregation); used during PCI, adjunct to thrombolysis

Abciximab
SimD: Eptifibatide, Tirofiban

7

Antiplatelet drug; ADP inhibitor

Clopidogrel
SimD: Ticlopidine, Prasugrel

8

Antiplatelet drug; inhibits PDE III and increases cAMP in platelets and blood vessels

Dipyridamole

SimD: Cilostazol (contraindicated in heart failure)

9

Heparin or warfarin?
Anticoagulation of choice for chronic therapy

Warfarin

10

Heparin or warfarin?
Oral route

Warfarin

11

Heparin or warfarin?
Site of action is liver.
Impairs post-translational modification of vitamin K-dependent factors.

Warfarin

12

Antidote for warfarin

Vitamin K, FFP

13

Antidote for heparin

Protamine sulfate

14

Laboratory test to assess
-- intrinsic pathway:
-- extrinsic pathway:

PTT
PT

MNEMONIC: PiTT, PeT

15

Heparin or warfarin?
MOA: Activates antithrombin III

Heparin

16

Direct thrombin ihibitor; used for HIT (heparin-induced thrombocytopenia)

Lepirudin

SimD: Dabigatran, argatroban, desirudin, bivalirudin,

17

Heparin or warfarin?
Skin necrosis due for transient prothrombotic effect.

Warfarin

NOTE:
Initial anticoagulant of choice:
Heparin
Heparin + warfarin (with overlap)

18

Tissue plasminogen activator analog

Antidote: _________________

Alteplase

SimD:
Streptokinase (can be used only once in a lifetime)
Anistreplase
Reteplase
Tenecteplase
Urokinase

Aminocaproic acid

19

Competitively inhibits plasminogen activation;
Contraindicated in DIC and genitourinary bleeding

Aminocaproic acid

SimD: Tranexamic acid

20

True or False.
Vitamin K (menadione) should never be used in therapeutics (ineffective).

True

21

A vasopessin V2 receptor agonist which increases factor VIII activity of patients with mild hemophilia A or von Willebrand disease

Desmopressin

22

__________ inhibits vitamin K epoxide reductase and thereby interferes with production of functional vitamin K-dependent clotting and anti-clotting factors.

Warfarin

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