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Flashcards in Drugs Used in Heart Failure Deck (6):
1

True or False.
Acute heart failure should be treated with a loop diuretic. If very severe, use prompt-acting positive inotropes (beta-agonists or PDE inhibitors) and vasodilators.
Chronic heart failure should be treated with diuretics (often loop plus spironolactone) plus an ACE inhibitor, and if tolerated, a beta-blocker. Digitalis may be helpful if systolic dysfunction is prominent.

True

2

What drugs (not necessarily used in heart failure) have narrow therapeutic index? (10)

WALA na Ciyang PaPa! Vasted na!
Warfarin
Aminoglycosides
Lithium
Amphotericin B
Carbamazepine
Phenobarbital
Phenytoin
Vancomycin
Theophylline
Digoxin

3

Antiarrhythmic which is the drug of choice for digitalis toxicity

Lidocaine

NOTE: The chemical antagonist for digoxin is digoxin antibodies (Fab fragments; Digibind).

4

True or False.
Dobutamine (beta-1 selective) and dopamine are useful in acute heart failure but are not appropriate for chronic failure because of tolerance, lack of oral efficacy and significant arrhythmogenic effects.

True

5

True or False.
Phosphodiesterase inhibitors should not be used for chronic heart failure because they increase morbidity and mortality.

True

6

What drugs have been shown to improve survival in cases of heart failure?

ABA! Buhay ka pa!
ACE-I
Beta-blockers
Aldosterone antagonists (potassium-sparing diuretics)

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