Flashcards in Drugs Used in the Treatment of Dyslipidemia Deck (12):
Drug of choice for high LDL
Statins a.k.a. HMG CoA reductase inhibitors
True or False.
Statins are usually given before bedtime because cholesterol synthesis predominantly occurs at night.
Statins are used in the management of coronary artery disease because they are able to stabilize atherosclerotic plaques through reduction of platelet aggregation.
Drug for dyslipidemia which is also used for pruritus in cholestasis. It increases triglycerides and VLDL in patients with high triglycerides.
SimD: colestipol, colesevelam
(bile acid-binding resins)
Ang Cholet, Colet, Colet mo! Sabi nang you should BAR this from people with high TAGs!
Its active glucuronide form is a selective inhibitor of the NPC1L1 transporter, decreasing intestinal nail absorption of cholesterol and other phytosterols. There is a synergistic LDL-lowering effect with statins; however, it becomes more hepatotoxic with statin use).
A cholesterol analog which takes the place of dietary and biliary cholesterol, thereby decreasing intestinal absorption of cholesterol and other phytosterols.
Most effective agent for increasing HDL levels.
Side effects include flushing, which can be pretreated with ______________.
Other more serious side effects include hyperuricemia and impaired glucose tolerance.
Niacin (Nicotinic acid; B3)
What drugs (not necessarily antidyslipidemic agents) cause flushing?
Calcium channel blockers
Drug of choice for hypertriglyceridemia. Activates PPAR-gamma and increases expression of lipoprotein lipase and apolipoproteins. There is increased risk of myopathy and rhabdomyolysis when used with statins.
Fibrates (gemfibrozil, fenofibrate, bezafibrate)
Fibrates Upregulate Lipoprotein Lipase
Synergistic combinations for familial hypercholesterolemia (2)
Statin + ezetimibe
Statin + niacin
Synergistic combinations for familial combined hypercholesterolemia (2)
Statin + fibrate
Niacin + resin
Disadvantage of statin + resin combination
Impaired statin absorption