DVT AND PE Flashcards
(19 cards)
Triples long term risk of VTE
Heart failure
Consistently linked to higher VTR risk
Smoking, adiposity and older age
Type of birth control pills not associated with VTE risk
Progesterone only pills
When is VTE incidence highest in a nursing home facility
First week after admission
Cancer risk for VTE how many?
4x risk than general population
Higher VTE risk? Solid or Liquid tumors?
Solid tumors but increases in liquid tumors if myeloproloferative, lymphoma or leukemia
Most common genetic cause of thrombophilia
Factor V Leiden and Prothrombin gene mutation
This disease triples the risk for VTE; once oral estrogen OCPs are given it increases risk by 10x
Factor V Leiden
This disease doubles the risk of VTE
Prothrombin gene mutation
Most common acquired thrombophilia
APAS
Fastest and most cost effective way to identify predisposition to VTE
Family history
Type of APAS that occurs without autoimmune manifestation?
Primary APAS
This medication depletes antithrombin
Warfarin
This medication causes mild deficiency of protein C and S
Warfarin
This condition and medication depresses protein S levels alone
Pregnancy and contraception
**S for single
🩸❓In a patient with PE with average bleeding risk, how will you start and maintain UFH?
IV BOLUS 80 u/kg/hr
IV DRIP 18 u/kg/hr
MAINTAIN APTT 1.5-2.5x control
MAINTAIN TX RANGE 60-80 secs and dose 0.3-0.7 units/mL
🩸❓How to start Warfarin if no initial UFH and how to maintain?
Overlap Warfarin with Heparin for 5 days (even if PT increases rapidly in between, full effect is after 5-7 days)
MAINTAIN INR 2-3
🩸❓How to give Alteplase in HIGH RISK PE?
Give 100 mg IV over 2 hours without concomitant HEPARIN
👆WARFARIN CAN DECREASE WHAT ENDOGENOUS ANTICOAGULANTS?
PROTEIN C AND S
