Dyslipidemia Flashcards Preview

Pharmacology I > Dyslipidemia > Flashcards

Flashcards in Dyslipidemia Deck (11):
1

MOA of MTP Inhibitor Lomitapide

- Inhibits MTP directly

- Prevents assembly of apolipoprotein-B

2

What is the MOA of Mipomersen Sodium (Kynamro)

Inhibitor of apolipoprotein B-100

3

What is the general MOA of Fibrates

1. Upregulates lipoprotein lipase (LPL) which increases the catobolism of VLDL

4

What is a concern while using Fibrates

They can INCREASE LDL in patients with high TG's

5

What are the major drug interactions while using Fibrates

1. Statins - can increase risk of myopathies

2. Sulfonylureas - DM

3. Warfarin - anticoagulants

6

What is the MOA for Nicotinic Acid (Niacin)

Inhibits synthesis and secretion of VlDL and LDL

7

What is the side effects of Nicotinic Acid. What can offset these conditions

Flushing.

Taking NSAIDS

8

What is the MOA of Bile Acid Sequestrants?

Binds with bile acids in the intestines and then eliminated via feces.

This increases bile acid exertion and increases cholesterol catabolism to form more

9

What is the MOA for fish oils

Thought to inhibit VLDL and TG production in the liver

10

What are the side effects of Omega 3 Fatty Acid

Eructation- fish burp
Dypepsia
Increase in LFT's

11

What are the Drug interactions of Omega 3 Fatty Acid

Anticoagulants and antiplatelets

This enhances bleeding time