Dyslipidemia

Question 1

Hyperlipiproteinemia associated with high incidence of acute pancreatitis

Answer 1

hyperchylomicronemia

Question 2

[Statins]

what is the MOA of statins

Answer 2

inhibit hepatic cholesterol synthesis by inhibiting HMG-COA

Question 3

Which drug causes the modest reduction in triglycerides?

Answer 3

statins

Question 4

[Statins]

Which of the following are prodrugs?

Answer 4

simvastatin and lovastatin

Question 5

[Statins]

Greater maximal effect than other statins

Answer 5

Rosuvastatin
Atorvastatin
Simvastatin

Question 6

resins are given at least how many hours after taking statins?

Answer 6

1 hour

Question 7

if resin was taken first, how many hours after will you give your statins?

Answer 7

4 hours after

Question 8

why are statins used in the management of CAD?

Answer 8

for plaque stabilization

Question 9

Bile acid resins lead to compensatory increase in ____

Answer 9

increase in high-affinity LDL receptors and increases LDL removal

Question 10

What are examples of bile acid resins?

Answer 10

1. Cholestyramine
2. Colestipol
3. Colesevelam

Question 11

bile acid resins can also be given to ____ toxicity

Answer 11

digitalis

Question 12

drug of choice for pruritus in cholestasis

Answer 12

cholestyramine

Question 13

what is the MOA of cholesterol absorption blockers?

Answer 13

inhibits NPC1L1 transporter

Question 14

What drug prevents the absorption of dietary cholesterol and cholesterol that is excreted in bile?

Answer 14

ezetimibe

Question 15

preferred drug for high LDL

Answer 15

ezetimibe

Question 16

a sterol absorption blocker that is a cholesterol analog that decreases intestinal absorption of cholesterol and other phytosterols

Answer 16

sitosterol

Question 17

sterol absorption blocker that can cause impotence (rare)

Answer 17

sitosterol

Question 18

niacin inhibits lipolysis by acting on what enzyme?

Answer 18

hormone sensitive lipase

Question 19

what is the most effective agent in increasing HDL level?

Answer 19

niacin

Question 20

____ decreases catabilism of ApoA-I.

Answer 20

niacin

Question 21

prominent side effects of this drug is flushing, pruritus, and rashes

Answer 21

niacin

Pretreat with aspirin to reduce flushing

Question 22

what are the drugs that can cause flushing?

Answer 22

Vancomycin
Adenosine
Niacine
CCBs

Question 23

___ are ligands for the peroxisome proliferator-activated receptor-alpha protein in which this drug will act to increase clearance of triglyceride

Answer 23

fibrate

Question 24

The DOC for hypertriglyceridemia

Answer 24

Gemfibrozil

Question 25

im combined with statin, gemfibrozil can increase the risk for?

Answer 25

myopathy and rhabdomyolysis

Question 26

[Know the DOC] I. Primary hyperchylomicronemia

Answer 26

low fat diet

Question 27

[Know the DOC] II. Familial hypercholesterolemia

Answer 27

statin

Question 28

[Know the DOC] III. Familial combined hypercholesterolemia

Answer 28

statin

Question 29

[Know the DOC] II. Familial dysbetalipoproteinemia

Answer 29

fibrate, niacin

Question 30

[Know the DOC] IV. Familial hypertriglyceridemia

Answer 30

fibrate, niacin

Question 31

[Know the DOC] V. Familial combined hypertriglyceridemia

Answer 31

fibrate, niacin

Question 32

[synergistic antihyperlipidemic cimbination] Niacin + statin

Answer 32

Familial hypercholesterolemia

Question 33

[synergistic antihyperlipidemic cimbination] statin + ezetimibe

Answer 33

familial hypercholesterolemia

Question 34

[synergistic antihyperlipidemic cimbination] Niacin + resin

Answer 34

familial combined hypercholesterolemia

Question 35

[synergistic antihyperlipidemic cimbination] statin + fibrate

Answer 35

familial combined hypercholesterolemia

Question 36

[disadvantageous combination] fibrate + resin

Answer 36

increased risk of cholelithiasis

Question 37

[disadvantageous combination] statin + resin

Answer 37

impaired statin absorption

Question 38

[disadvantageous combination] statin + fibrate

Answer 38

increased risk of myopathy and rhabdomyolysis

Question 39

___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis

Answer 39

probucol

Question 40

[disadvantageous combination] fibrate + resin

Answer 40

increased risk of cholelithiasis

Question 41

[disadvantageous combination] statin + resin

Answer 41

impaired statin absorption

Question 42

[disadvantageous combination] statin + fibrate

Answer 42

increased risk of myopathy and rhabdomyolysis

Question 43

___ is an antioxidant that can inhibit the oxidation of LDL and lowers the level of cholesterol in the blood stream, inhibit early stages of cholesterol biosynthesis

Answer 43

probucol

Question 44

myalgia among patients taking Statins is due to?

Answer 44

blockage of farnesyl pyrophosphate can also affect NaK ATPase. This leads to cell swelling presenting as myalgia

Question 45

Niacin-induced flushing can be treated with

Answer 45

Niacin 200mg | Aspirin

Question 46

Bile acid resin is absorbed in what part of GIT?

Answer 46

terminal ileum

Question 47

____ lipid lowering drug that can also cause cholelithiasis?

Answer 47

fenofibrate