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Flashcards in EM Neuro Deck (64)
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1

What's the most sensitive NCS?

Sensory NCS, on the sural nerve

2

On EMG, fibrillation potential, or positive sharp waves, are a clear sign of?

Denervation

3

On EMG, prolonged, polyphasic, increased amplitude of motor units = ?

Neuropathic process. Prolonged amplitude, because there are more muscle fibres than usual firing off (muscle units belonging to dead nerves get recruited by living ones). Polyphasic, because recruited muscle fibres lie outside the main area of the motor unit.

4

EMG with brief, low amplitude units, and early interference pattern = ?

Myopathic process. Disease which randomly knocks off muscle fibres.

5

If you see fibrillations (clinically) & sharp waves on EMG, you should think..?

ALWAYS think neuropathy (at least for BPT exam!)

6

Ramsay Hunt syndrome caused by? Bell's?

HZV (aka VZV).

7

T/F? There's evidence that antivirals within 72 hrs of Ramsay Hunt Syndrome developing will improve progonosis

True

8

T/F? R) MCA infarct (posterior division) can cause neglect

True, often in multiple areas, eg auditory, sensory, visuospatial. eg) pt fails intersecting pentagons on MMSE, difficulty putting on jacket, crowds all the numbers on the R) side of the clock face

9

How do you diagnose a small fibre neuropathy?

Skin biopsy - see destruction of small epidermal nerves.

10

What cells are causing MS? what do they secrete?

Th1 cells, secrete IFN-gamma. (NB: IFN-alpha is treatment for MS)

11

The most common cause of epilepsy in those > 65 yrs is?

Previous strokes

12

In paraneoplastic disorders, would ataxia be seen unilateral or bilateral (symmetrically)?

Symmetrical

13

Where would you expect to see brain mets?

Lodged between grey-white interface, where the vessels are the narrowest. However, brain mets can be anywhere.

14

What nerve involvement in VZV would mimic a presentation of meningitis?

Greater occipital nerve - goes in a path that when irritated can cause neck stiffness

15

Pt p/w ataxia, confusion, ophthalmoplegia, lateral gaze difficulty. Diagnosis?

Alcohol related nerve injury - treat with thiamine. Pts often have residual deficit - amnestic MCI.

16

Wernicke's encephalopathy carries what mortality rate?

1-2%. This condition is potentially reversible with thiamine

17

A pt with NHL p/w multiple nerve root involves (including CN 6 palsy, weakness in L5 distribution, diplopia, bladder disturbance, leg weakness, reduced / a/reflexia). Dx?

Lymphoma recurrence - multiple meningeal disease

18

With regards to postherpetic neuralgia, if simple analgesics (paracetamol, NSAIDs) fail, what is the next line of management?

Gabapentin (pregabalin similar efficacy; if one doesn't work though, try the other, sometimes a person will get a response). NNT = 3.

19

Name two indications for pregabalin (or gabapentin)?

Postherpetic neuralgic treatment (NNT = 3), DM neuropathy

20

What is the biggest risk factor for chronicity of postherpetic neuralgia?

Increasing age

21

What's the most appropriate first-line AED for JME?

Valproate. Change to lamotrigine if pre-pregnancy.

22

Which investigation best provides diagnosis for narcolepsy?

Mean sleep latency test

23

The following are classic symptoms of what? Excessive daytime sleepiness, catalpesy, hyponogogic hallucinations

Narcolepsy

24

What is a 'positive' (or 'abnormal') result in the mean sleep latency test?

Time for someone to fall asleep is

25

What's the treatment of narcolepsy?

Retanil - dexamphetamine

26

T/F? With regards to MS, PML has no mass effect and does not enhance on MRI brain

True. It's black on T1, white on T2, involves subcortical U-fibres, and is multifocal.

27

What's the baseline risk of PML for those with MS on natalizumab?

1 in 1000

28

What is wrong in PML?

PML is oligodendrocyte infection from JCV

29

What sort of vision do you get with an optic chiasm defect? How about an optic tract lesion? Posterior circulation stroke?

Optic chiasm - get tunnel vision

30

What causes myasthenia gravis?

Acetylcholine antibodies