Emerging mechanisms in compulsivity Flashcards
What are 5 features of autism?
Anxiety & depression
seizures
attention deficits/hyperactivity
aggressive behaviour
sleep disorders
What 4 areas of the brain does insulin affect?
Hippocampus
prefrontal areas
hypothalamus
fusiform gyrus
Where in the brain is insulin locally produced?
Epithelial cells of brain ventricles
What happens to recptors in T2DM?
Decoupling of intracellular insulin signalling
What are the 4 insulin receptors?
Insulin receptor
Hybrid receptor
IGF1 receptor
IGF2 receptor
What do the receptors bind to first?
IRS
What are 3 signaling pathways in insulin signalling?
mTOR
AKT
RAS
What are 4 main consequences of the insulin signalling pathways?
Apoptosis
Oxidative stress
protein translation
autophagy/mitophagy
What pathway does the RAS system go to?
MAPK -> gene expression & tau
What 2 neurodegenerative diseases are associated with tau?
Alzheimers
Parkinsons
What is PTEN important in?
Cognition
What is APP?
Beta amyloid precursor protein
What 5 glucose transport isoforms are found in the brain?
GLUT 1- 4
GLUT 8
What do miRNAs inhibit?
mRNA & gene transcription
What is mTOR involed with?
Protein degradation
autophagy
mitophagy
