Emetics Vs Antiemetics

Question 1

Centrally acting emetics - General

Answer 1

Morphine derived, stimulates dopamine receptors in crtz, bad by mouth, don’t use in cats, tablets or injections, SE = vomiting, restlessness, respiratory depression, CNS depression

Question 2

Xylazine

Answer 2

Sedative, emetic of choice in cats, stimulates alpha receptors, emetic dose lower than sedative dose, only injected, Brady cardia, resp. Depression

Question 3

Locally acting emetics

Answer 3

Home remedies, 
hydrogen peroxide, 
mustard and water, 
salt solution, 
salt and water

Question 4

phenothiazine derivatives

Answer 4

Anti emetic, centrally acting, block dopamine receptors, common use, treats motion sickness, SE = sedation, ataxia, hypotension, lower seizure threshold

Question 5

acepromazine chlorapromazine, prochloperzine, and perphenazine belong to what group? Anti emetics or emetics?

Answer 5

Phenothiazine derivatives; anti emetics

Question 6

Antihistamines

Answer 6

Antiemetic, treats motion sickness/inner ear issues/vaccine reactions, can cause sedation

Question 7

trimethobenzamide belongs to what group? Antiemetic or emetic?

Answer 7

Antihistamines; antiemetic

Question 8

Anticholonergics

Answer 8

Block acetacholine at parasympathetic nerve endings, ⬇️GI Motility/secretions/speed of emptying, SE = dry mm, urinary retention, tachycardia, constipation

Question 9

atropine, propantheline, glycopyrrolate belong to what group? Antiemetic or emetic?

Answer 9

Anticholinergic; antiemetic

Question 10

Procainamide derivatives

Answer 10

Centrally acting, ⬆️gastric contractions/emptying, strengthens cardiac sphincter tone, short half life, oral and parenteral(iv), don’t use with GI obstructions/perforations/hemorrhage/animals with epilepsy

Question 11

metoclopramide belongs to what group? Antiemetic or emetic?

Answer 11

Procainamide derivatives; anti emetic

Question 12

Serotonin receptor antagonist

Answer 12

Centrally and IV acting, blocks release of serotonin, expensive

Question 13

Ondansetron (Zofran), propantheline (Anzemet), granisetron are a part of what group? Antiemetic or emetic?

Answer 13

Serotonin receptor antagonists; antiemetics

Question 14

NK-1 receptor antagonist

Answer 14

Block substance P, tablets and injections, cats and puppies too!, SE = diarrhea, bloody stool, anorexia, endotoxic shock, hypersalivation

Question 15

maropitant citrate is a part of what group? Antiemetic or emetic?

Answer 15

NK-1 receptor antagonists ; antiemetic