Endo Flashcards Preview

LAST MINUTE! > Endo > Flashcards

Flashcards in Endo Deck (28):
1

Tesamorelin

GHRH analog for HIV lipodystrophy

2

ADH-Rs

V1 = BP
V2 = Osmolarity

3

permissive effect of cortisol

upregulated a1-Rs on BVs
so when NE release it can cause VC

4

inc/dec TBG via:

increase via OCP/pregnancy (still euthyroid; total T4 increased but free T3/T4 amt same)

decrease via liver failure or steroids

5

wolff-Chaikoff

excess iodine inhibits TPO activity

6

NIS competitive inhibitos

Pertechnetate
Perchlorate
Thiocyanate

7

anti TPO

excessive iodine
propothyouracil (also inhibits 5'deiodinase)
Methimazole (DOC unless pregnant)

8

anti 5'deiodinase

PTU
b-clockers
ipodate (contrast)
glucocorticoids
amiodarone

9

metyrapone stimulation test

blocks 11-b-OHase
so no cortisol, no inhibition of CRH/ACTH, ACTH should increase
[in 2' adrenal insufficiency, there is no increase in ACTH because you can't make it]

10

CRH stimulation test for:

cushing disease (AP tumour) vs ectopic ACTH
[can also use high dose DEX test]

11

Addisons pathophys

TB, mets, autoimmune

12

phew rule of 10s

10%:
- bilateral
- kids
- malignant
- extra-adrenal
- calcify

13

DeQuervains

Granulomatous, mixed cellular infiltrate, giant cells
High ESR
Jaw pain

14

IgG4-related systemic disease

- Reidel's thyroiditis
- autoimmune pancreatitis
- Retroperitoneal fibrosis
- Non-infectious aortitis

15

random marker of thyroid storm

high ALP (from bone turnover)

16

Graves rx causing worsening opthamology

radioablation

17

artery with recurrent laryngeal nerve

inferior thyroid a.

18

papillary CA thyroid

- Orphan annie
- nuclear grooves
- RET and BRAF
- psammoma
- lymphocytic infiltrate

19

follicular CA thyroid

- RAS
- hematogenous mets

20

Vagus branches

Superior:
- external = cricothyroid
- internal = sensory above vocal cords

Recurrent laryngeal:
- all larynx muscles except cricothyroid
- sensory below vocal cords

21

Albright disease

pseudohypoparathyroidism:
- kidneys dont sense PTH
- hypoCa++, short, short 4th + 5th digits, AD, round facies, mild mental retardation

22

McCune-Abright disease

example of mosaicism (only survivable is mosaic)
- altered G-protein signalling
- unilateral cafe-au-lait, precocious puberty, polystotic fibrous dysplasia, multiple endocrine problems

23

defective PTH sensing vs. Ca++ sensing

PTH = albright
Ca = hereditary hypocalciuric hypercalcemia

24

increased cAMP in urine

hyperparathyroidism because PTH signals through Gs

25

nephrogenic DI causes and rx

hereditary
hypercalcemia
lithium
demeclocycline

rx = HCTZ, amiloride, INDOMETHACIN (PG clocks ADH, so decrease it)

26

TIDM HLA

DR3 and DR4

27

glucagonoma s/s

- Dermatitis (necrolytic migratory erytema)
- Depression
- Diabetes
- DVT

28

positive secretin stimulation test

Zollinger-Ellison
gastrin levels remain elevated after secretin (supposed to stop it)