Endo 9 - Obesity Flashcards Preview

HD3 Endocrine > Endo 9 - Obesity > Flashcards

Flashcards in Endo 9 - Obesity Deck (26):
1

NE/Epi effect on HSL

increase HSL activity

2

function of HSL

lipolysis (pulls fat out of cells)

3

GH/cortisol effect on HSL

increase HSL activity

4

glucagon effect on HSL

increase HSL activity

5

3 things that increase NE/glucag/GH

fasting
exercise
stress

6

insulin upregulates what enzyme

LPL = more fat into cells

7

insulin blocks what enzyme

HSL

8

most common obesity risk gene

FTO

9

major hormone that suppress food intake

leptin

10

leptin blocks

NPY
AgRP

11

NPYr activation =

FOOD

12

AgRP blocks

melanocortin receptor

13

melanocortin receptor normally =

STOP FOOD

14

location of NPY, AgRP, MSH

Arcuate nucleus

15

location of NPYr and McR

Paraventricular nucleus

16

leptin activates

POMC -> MSH

17

MSH activates

McR

18

T/F high value foods have different brain representations

TRUE

19

what makes us stop eating, weight or calories

weight

20

set point theory =

weight is in homeostasis

21

settling point theory =

set point fluctuates based on input and output

22

3 types of obesity from periphery

system wide metabolic error
fat/muscle function error
nutrient partitioning failure

23

at what bmi does t2dm risk go way up

>35

24

where is bad fat stored

abdomen

25

best rate to lose pounds

1-2 lb/week

26

when should maintenance be started

6 months after continuous loss