Endo (Drugs that Affect Bone and Mineral Homeostasis) Flashcards Preview

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Flashcards in Endo (Drugs that Affect Bone and Mineral Homeostasis) Deck (8):
1

Parathyroid hormone
- promotes bone turnover by increasing the activity of both osteoblasts and osteoclasts
- Synthesis and secretion of PTH is primarily regulated by the serum concentration of free ionized calcium. ___________ free ionized calcium stimulates PTH release.
Signs and symptoms of excess PTH: (4)

Parathyroid hormone
- promotes bone turnover by increasing the activity of both osteoblasts and osteoclasts
- Synthesis and secretion of PTH is primarily regulated by the serum concentration of free ionized calcium. Decreased free ionized calcium stimulates PTH release.
Signs and symptoms of excess PTH: (4)
Painful bones, renal stones, abdominal groans, psychiatric overtones

2

Recombinant PTH
Used for osteoporosis (must be administered in low intermittent doses to stimulate bone formation)

Teriparatide

3

PTH, Vitamin D, or both?
1) Increases Ca and P absorption in the intestines
2) Increases resorption of calcium and phosphate in the kidneys
3) Promotes bone mineralization by increasing availability of Ca and P
4) Serum calcium and phosphate both increased

1) both
2) vitamin D
3) vitamin D
4) vitamin D

4

_______ vitamin D: cholecalciferol, ergocalciferol
- for vitamin D deficiency (rickets, osteomalacia)

_______ vitamin D: calcitriol
- for secondary hyperparathyroidism in CKD, hypocalcemia in hypoparathyroidism

Inactive vitamin D: cholecalciferol, ergocalciferol
Active vitamin D: calcitriol

5

Calcitonin
- secreted by the ________________ cells in the _________ gland
- decreases serum calcium and phosphate by inhibiting bone resorption and inhibiting renal excretion of these minerals
- bone formation is not impaired, but ultimately it is reduced.
- Used for Paget's disease of bone, hypercalcemia, osteoporosis
- tumor marker for thyroid cancer
- administered as NASAL SPRAY

Calcitonin
- secreted by the parafollicular C cells in the thyroid gland
- decreases serum calcium and phosphate by inhibiting bone resorption and inhibiting renal excretion of these minerals
- bone formation is not impaired, but ultimately it is reduced.
- Used for Paget's disease of bone, hypercalcemia, osteoporosis
- tumor marker for thyroid cancer
- administered as NASAL SPRAY

6

Bisphosphonate
Suppresses activity of osteoclasts
Inhibits bone resorption
Used for Paget's disease of bone, hypercalcemia, osteoporosis
Contraindicated in things with renal impairment, esophageal motility disorders and peptic ulcers

Alendronate

7

Phosphate-binding resin
Used for hyperphosphatemia in CKD, hypoparathyroidism, Vitamin D intoxication
Can significantly reduce uric acid levels

Sevelamer

8

Calcium supplement with highest percentage of elemental calcium?
Lowest?

Calcium carbonate
Calcium glubionate (low-bionate)

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