Endo (Gonadal Hormone Agonists and Antagonists) Flashcards Preview

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Flashcards in Endo (Gonadal Hormone Agonists and Antagonists) Deck (14):
1

Major ovarian estrogen in women

Estradiol

2

Used for primary hypogonadism, postemnopausal hormonal replacement therapy, osteoporosis, contraception, intractable dysmenorrhea
Increases risk of endometrial CA and breast cancer (prevent by combining with progestin)
A. Ethinyl estradiol
B. Diethylstylbestrol
C. Norgestrel
D. Estradiol + norethindrone
E. Medroxyprogesterone acetat
F. Levonorgestrel
G. Tamoxifen
H. Raloxifene
I. Clomiphene

Ethinyl estradiol

3

Activates progesterone receptors
A. Ethinyl estradiol
B. Diethylstylbestrol
C. Norgestrel
D. Estradiol + norethindrone
E. Medroxyprogesterone acetat
F. Levonorgestrel
G. Tamoxifen
H. Raloxifene
I. Clomiphene

Norgestrel

4

Used for emergency contraception
Thickens cervical mucus. Inhibits ovulation.
Must be taken 72 hours of unprotected sexual intercourse
Yuzpe regimen for combination emergency contraception
A. Ethinyl estradiol
B. Diethylstylbestrol
C. Norgestrel
D. Estradiol + norethindrone
E. Medroxyprogesterone acetat
F. Levonorgestrel
G. Tamoxifen
H. Raloxifene
I. Clomiphene

Levonorgestrel

5

SERM
Used for hormone-responsive breast cancer
Prevents osteoporosis and decreases risk of atherosclerosis
at the risk of causing endometrial cancer

Tamoxifen (tanggal ang mammary mo)

6

SERM
Used for breast cancer prevention, for osteoporosis
No estrogenic effects on endometrial tissue

Raloxifene

7

SERM
Used for induction of ovulation

Clomiphene (Clone Mi Phlease)

8

Estrogen synthesis inhibitor
Inhibits aromatase
Used for breast cancer, for precocious puberty
A. Anastrozole
B. Danazol
C. Leuprolide
D. Ganirelix
E. Mifepristone

Anastrozole

9

Ovarian inhibitor (antiandrogen)
Used for endometriosis, fibrocystic disease, hemophilia, angioneurotic edema
Contraindicated during pregnancy and breast-feeding
A. Anastrozole
B. Danazol
C. Leuprolide
D. Ganirelix
E. Mifepristone

Danazol

10

Pharmacologic antagonist of glucocorticoid and progesterone receptors
Used for medical abortion, Cushing's syndrome
Combination with misoprostol results in abortion of 95% of early pregnancies
May cause sepsis due to unusual organisms (Clostridium sordelli)
A. Anastrozole
B. Danazol
C. Leuprolide
D. Ganirelix
E. Mifepristone

Mifepristone (RU-486)

11

Anabolic steroid
A. Oxandrolone
B. Flutamide

Oxandrolone

12

Androgen antagonist
GnRH analogs (leuprolide) must be co-administered with this to prevent acute flare-up of prostate cancer
A. Oxandrolone
B. Flutamide

Flutamide

13

Androgen antagonist used for surgical castration

Nilutamide (niluto ang balls mo)

14

5-alpha reductase inhibitor
Used for BPH, male pattern baldness, hirsutism

Finasteride (FinAsteRIde Five-Alpha Reductase Inhibitor)
SimD: Dutasteride

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