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Flashcards in Endocrine Deck (15):
1

Name the screening test for growth hormone excess

IGF 1

2

Name the screening test for Cushing

24 hour free urinary cortisol Serum ACTH levels

3

Thyrotoxic myopathy affects which group of muscles

Shoulder girdle muscles

4

An association of thyrotoxic myopathy

Hypokalemic periodic paralysis

5

Five step mechanisms of the action of Sulfonylureas

  1.  .Binds to the sulfonylurea receptors on the beta cells
  2. Blocks ATP dependent K channels
  3. Depolarisation
  4. Ca Influx
  5. Release of insulin

6

Does increase insulin levels increase cardiovascular risk

Yes

7

Where are most of the sulfonylureas metabolized and excreted

metabolised in the liver and excreted in the kidney

8

Name the two classes of insulin secretogogues

Sulfonylureas

Non sulfonylureas

9

Name the Non sufonylurea insulin secretogogues

MEGLITINIDES

Repaglinide

Nateglinide

10

Can sulfonylureas impair cardiac functioning

Yes.

sulfonylureas binds to the myocytes and blocks K channels and thus impairs ischemic preconditioning

11

Three important difference between MEGLINITIDE and SULFONYLUREA

MEGLINITIDE

  • Rapid and short duration of action
  • Less weight gain
  • Safer in renal failure

12

Two important mechanism of METFORMIN

  1. Reduces hepatic production of glucose
  2. Increases peripheral sensitivity of insulin

13

List the six contraindications for metformin

Cardiac Failure

Hepatic failure

Renal failure

Dehydration

Metabolic Acidosis

Alcoholism

14

Which has a greater cardiovascular risk

post prandial hyperglycemia or FBS

Post prandial hyperglycemia

15

What is the mode of action of a THIAZOLIDINEDIONE

It is a pharmacologic ligand for a nuclear transcription factor PPAR G.

(Peroxisome Proliferator Activator Receptor-Gamma)