endocrine disorders pharmacokinetics/adverse reactions/dosage Flashcards Preview

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Flashcards in endocrine disorders pharmacokinetics/adverse reactions/dosage Deck (49):
1

 

 

cinacalcet adverse reactions

 

 

  • CV: arrythmias, chest pain
  • GI: vomiting, diarrhea
  • MS: muscle aches/cramps, sudden tightening of muscles in hands, feet, face, throat
  • NEURO: dizziness, weakness, burning, tingling, unusual feeling in lips, tongue, fingers, or feet, seizures

2

 

 

vasopressin adverse reactions

 

  • CV: MI, diaphoresis
  • DERM: rash, skin blanching, pallor
  • GI: N/V, diarrhea
  • NEURO: dizziness
  • MISC: anaphylaxis, pain at injection site, water intoxication

3

 

 

desmopressin adverse effects

 

 

  • CV: acute MI, thrombosis, facial flushing, edema, HTN, palpitations
  • EENT: rhinorrhea/nasal congestion from nasal spray
  • GI: abdominal cramps, nausea
  • GU: decreased urination
  • META: water intoxication, rapid weight loss
  • NEURO: agitation, coma, headache, insomnia, confusion, seizures

4

 

 

Syntroid, Levoxyl, unithroid pharmacokinetics

 

 

page 200

5

 

 

Synthroid, Levoxyl, Unithyroid (T4)

adverse reactions

 

 

  • CV: tachycardia
  • DERM: urticaria
  • META: heat intolerance
  • NEURO: tremors, rash

6

 

liothyronine

(Cytomel, Triostat)

pharmacokinetics

 

 

 

 

 

page 201

7

 

 

T4 dosage

 

50mcg initially

may be increased every 2-3 weeks

8

 

 

liothyronin dosage

 

 

5mcg/day

may increase by 5-10mcg/week

9

 

 

liothyronine maintenance dose for myxedema goiter

 

 

75 mcg daily

10

 

 

liothyronine adverse reactions

 

 

  • CV: arrythmias, tachycardia
  • DERM:reversible hair loss in children at begining, dry skin, rash, hives
  • GI: intolerance
  • NEURO: headaches

11

 

 

dosage of liotrix

 

 

50/12.5 mcg then double every month until desired results are achieved

12

 

 

liotrix adverse reactions

 

  • CV: CARDIOVASCULAR COLLAPSE, arrythmia, tachycardia, HTN
  • DERM: increased sweating
  • ENDO: hyperthyroidism, menstrual irregularities
  • GI: N/V, cramps
  • META: weight loss, heat intolerance
  • MISC: accelerates bone maturation in children
  • NEURO: insomnia, irritability, nervousness, headache

13

 

 

PTU pharmacokinetics

 

 

page 204

14

 

 

PTU dosage guidelines

 

 

page 204

15

 

 

PTU adverse reactions

 

  • DERM: hair loss, pruritis, rash, skin pigmentation, urticaria
  • GI: nausea
  • HEM: agranulocytosis can occur as long as 4 months after therapy and can cause fatal hepatitis
  • MISC: lupus-like syndrome
  • NEURO: headache, paresthesia

16

 

 

methimazole pharmacokinetics

 

 

page 205

17

 

 

dosing of methimazole

 

 

start with 15-60mg as single or divided doses for 6-8 weeks

18

 

 

cinacalcet pharmacokinetics

 

 

page 207

19

 

 

calcitrol pharmicokinetics

 

 

page 208

20

 

 

calcijex dosage/administration

 

 

injection 0.5-4mcg every other day

21

 

 

rocaltrol dosage/administration

 

 

PO: 0.25-1mcg/day

22

 

 

calcitrol adverse reactions

 

  • CV: arrythmias
  • GI: constipation, metallic taste, nausea
  • META: hypercalcemia, polyuria
  • NEURO: headach, irriability

23

 

 

vasopressin pharmacokinetics

 

 

page 209

24

 

 

vasopressin dosage guidelines

 

 

page 209

25

 

 

oxytocin pharmacokinetics

 

 

page 210

26

 

 

oxytocin adverse reactions

 

  • CV: tachycardia, premature ventricular contractions, hypotension (mom and baby)
  • EENT: neonetal retinal hemorrhage
  • GI: N/V in both
  • MISC: prolonged IV infusion has caused severe water intoxication with seizures, coma, and death
  • OB/GYN: postpartum hemorrhage in mother

27

 

 

desmopressin pharmacokinetics

 

 

page 210

28

 

 

desmopressin (DDAVP, stimate) dosage information

 

 

page 210

29

 

 

lypressin pharmacokinetics

 

 

page 211

30

 

 

lypressin dosing

 

 

nasal spray, 1-2 sprays per nostril QID

(adults and children over 12)

31

 

 

lypressin adverse reactions

 

  • CV: chest tightness, SOB, dyspnea
  • EENT: eye pain/irritation, itching, irritation or sores inside nose, runny/stuffy nose
  • GI: abdominal/stomach cramps, increased BM, heartburn
  • NEURO: coma, confusion, convulsions, drowsiness, headache, weight gain, problems with urination

32

 

 

Actual practice dosage of lypressin

 

 

ranges from 1 spray at bedtime to 10 sprays every 3-4 hours

33

 

 

adverse reactions of somatrem and recombinant somatropin

 

  • CV: edema of hands anf feet
  • ENDO: hypoglycemia, hypothyroidism, insulin resistance
  • MISC: pain at injection site

34

 

 

pharmacokinetics of octreotide (Sandostatin)

 

 

page214

35

 

 

dosage of octreotide (Sandostatin)

 

 

page 214

36

 

 

octreotide (Sandostatin)

adverse reactions

 

  • CV: sinus bradycardia, arrhythmias
  • ENDO: hypothyroidism
  • GI: gallbladder abnormalities (stones and biliary sludge), diarrhea, N/V, abdominal discomfort, gas, distention, constipation
  • META: hypoglycemia or hyperglycemia can develop in acromegaly patients

37

 

 

glucocorticoid pharmacokinetics

 

 

page 215

38

 

 

glucocorticoid mechanism of action:

glucose metabolism, inflammation/immune function, other effects

 

 

page 215

39

 

glucocorticoids adverse reactions

 

  • CV: tachycardia
  • DERM: acne, delayed wound healing, facial flushing
  • ENDO: hyperglycemia, cushings syndrome
  • GI: abdominal distention, diarrhea, constipation, heartburn, increased appetite, peptic ulcers, GI bleeds
  • MISC: increased susceptibility to infections, allergic reactions
  • NEURO: anxiety, insomnia, mood swings, hallucinations, depression

40

 

 

fludrocortisone (Florinef) pharmacokinetics

 

 

page 217

41

 

 

fludrocortisone (Florinef dosage

 

 

page 217

42

 

 

fludrocortisone adverse reactions

 

  • DERM: acne
  • GI: ulcers, increased appetitie, abdominal distention, upset stomach, vomiting
  • META: cold, unusual hair growth
  • MISC: potential for decreases in inflammatory and immune responses, weight gain, swollen limbs
  • NEURO: dizziness, headaches, exaggerated sense of well-being, insomnia, mood swings, depression, anxiety

43

 

 

aminoglutamide (Cytadren) 

pharmacokinetics

 

 

page 218

44

 

 

aminoglutamide (Cytadren) dosage

 

 

page 218

45

 

 

aminoglutethimide (Cytadren)

adverse reactions

 

  • GI: nausea, anorexia (first few weeks)
  • NEURO: drowsiness, dizziness, headache, weakness

46

 

 

anastrozole (Arimedex)

pharmacokinetics

 

 

page 219

47

 

 

anastrozole (Arimedex) dosage

 

 

page 219

48

 

 

anastrozole (Arimedex)

adverse reactions

 

  • CV: peripheral edema
  • GI: N/V
  • GYN: vaginal bleeding, hot flashes
  • MISC: flu syndrome, cataracts
  • MS: fracture, sore muscles, fatigue, accidental injuries
  • NEURO: mood disturbances

49