Enteroviruses Flashcards Preview

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Flashcards in Enteroviruses Deck (16):
1

name the picornaviruses

structure/genome?

hepatitis A

rhinovirus

enterovirus(polio/non-polio)

 

small, naked ssRNA(+)

2

enterovirus transmission in general?

fecal-oral, resp. droplets, fomites

3

seasonality for enteroviruses?

summer/autumn

likes tropical/warm climates

4

describe the general pathogenesis of enteroviruses

  1. enter through respiratory tract/esophagus
  2. replicate in pharynx/intestine regional lymph nodes days 0-3
  3. move to blood(minor viremia) days 3-7; minor hillness
    1. goes to reticuloendothelial
  4. major viremia days 7-21; major illness
    1. goes to target organ(skin/mucosa, muscle, heart, brain, meninges)

5

poliovirus has tropism for what tissue?

CNS

specifically, the anterior horn of the spinal cord

can attack other locations, further defining how the disease manifests

6

describe the progression of paralytic polio infection

how else can polio resolve if non-paralytic

can be asymptomatic, non-specific, aseptic meningitis OR progress to paralytic polio

Clinical manifestation of paralyticpolio: biphasic

  1. Minor illness at first
  2. high fever, intense myalgia, loss of deep tendon reflex
    • Sudden onset of asymmetric paralysis or paresis
    • Max weakness @ day 5
    • Proximal>distal; lower>upper

7

describe the polio vaccines

Inactivated polio Vaccine(IPV) - Salk, 1955 - killed

  • Great systemic immunity, can be combined, effective in tropics
  • Injection only, less local immunity

Oral Polio Vaccine(OPV) - Sabin, 1961 - live attenuated

  • Great systemic and local, easy to give, well accepted
  • CAN MUTATE AND CAUSE PARALYSIS; don’t use in US anymore

8

factors that affect the spread of polio

Warm weather favors the spread of disease through contact between individuals participating in water activities. Factors that affect spread include crowding, hygiene, and water quality

9

non-polio enteroviruses

coxsackie

echovirus

#d enteroviruses

10

skin/mucosal manifestations of non-polio enteroviruses

Herpangina/stomatitis

  • painful vesicles on soft palate/pharynx
  • fever, HA, sore throat

Hand-foot-mouth disease 

  • vesicular stomatitis
  • vesicles/papules on hands, feet, groin; painful
  • fever, HA, sore throat

 

11

most common cause of community acquired aseptic meningitis?

enteroviruses

all of them can cause it

12

CNS infections involving non-polio enteroviruses

aseptic meningitis

encephalitis

poliomyelitis-like syndrome

 

13

muscle manifestations of non-polio enteroviruses

pleurodynia - inflammation of chest wall; fever; spasmotic chest pain

myositis - fever, chills, muscle pain(thighs); myoglobinuria/emia

myocarditis - inflammation of pericarditis; necrosis/inflammation; dilated cardiomyopathy due to fibrous recovery

14

eye manifestation of non-polio enteroviruses

acute hemorrhagic conjunctivitis 

  • shed in tears; highly contagious
  • hemorrhages under conjunctiva
  • eye pain/photophobia

15

manifestation of neonatal infections of non-polio enteroviruses

mimics sepsis

multi-system

often fatal

16

systems potentially infected by non-polio enteroviruses

skin/mucosa

CNS

muscle

eye

BABY SYSTEM(neonates)