Environmental/Nutrition - Review Flashcards Preview

PBD II Exam 1 > Environmental/Nutrition - Review > Flashcards

Flashcards in Environmental/Nutrition - Review Deck (37):
1

EIDs that have recently entered humans

HIV and SARS

2

EIDs with recent increase in humans

dengue fever

3

majority of EIDs

bacteria and rickettsia

4

climate change cause what

cardiovasc, cerebrovasc, resp diseases

gastroenteritis

vector borne infectious disease

malnutrition

5

most solvents and drugs

lipophilic

blood - lipoprotein transport

penetrate plasma membranes

6

CYP inhibitors

fasting and starvation

7

altered mucociliary clearance in adults

acid aerosols

8

lung inflammation

ozone in healthy adults and children

9

increased asthma attacks

particulates

10

individuals with chronic lung disease

increased mortality - sulfur dioxide

decreased lung function - particulates

11

athletes and outdoor workers decreased capacity

ozone

12

6 outdoor air pollutants

sulfur dioxide
ozone
nitrogen dioxide
particulates
lead
CO

all make up smog

13

wrist drop and foot drop in adults

peripheral demyelinating neuropathy

lead poisoning

14

basophilic stipling of RBCs

lead poisoning

15

minimata disease

mercury poisoning

cerebral palsy, binldness, mental retardation, CNS defects in utero
-developing brain extremely sensitive to methyl mercury

intracellular glutatione
-thiol doner - protects against mercury induced CNS and kidney damage

16

Tx of relapsing acute promyelocytic leukemia

arsenic trioxide

17

exposure to arsenic

soil and water - bangladesh, chile, china
-mines and smelting
-preservers, herbicides, agro products

18

sources of cadmium

mining, electroplating, battery production, zinc smelting`

19

benzene exposure

leukemia

20

organic solvents

chloroform and CCl4

-CNS depression
-low levels toxic to kidney and liver

21

scrotal cancers

soot in chimney sweeps

22

organochlorines

synthetic and lipophilic - resist degradation

ex/ DDT

endocrine disruptors

23

chloracne

folliculutis and dermatosis

caused by dioxins and PCBs

around face and behind ears

PCBs also induce CYPs - altered drug metabolism

24

pneumoconioses

non-neoplastic lung diseases caused by inhalation of mineral dust

coal dust, silica, asbestos, beryllium

often in workplace

25

vinyl chloride

angiosarcoma of liver

26

dioxins and PCBs

nonpesticide organochlorides

cause chloracne

27

nicotine

alkaloid that causes release of catecholamines

increased HR and BP

28

N-nitrosonornicotine

NNN
carcinogen in tobacco smoke

to esophagus and oral cavity

29

smoking and alcohol use

increased risk of laryngeal cancer

30

maternal smoking

increased spontaneous abortions and preterm births
growth retardation

31

cotinine

to estimate passive smoke inhalation

32

ADH

in cytosol of hepatocyte

33

vit b1

thiamine deficiency

peripheral neuropathies

wernicke-korsakoff

with chronic alcoholics

34

acute and chronic pancreatitis

with chronic alcohol use

35

breast ca in HRT

lobular carcinomas
ductal-lobular cancer

36

oral contraceptive reduces what anticoag factors

protein S

antithrombin III

37

bleomycin

interstitial fibrosis