Enzyme Nomenclature and Co-enzyme Chemistry Flashcards Preview

MCM Test 1 > Enzyme Nomenclature and Co-enzyme Chemistry > Flashcards

Flashcards in Enzyme Nomenclature and Co-enzyme Chemistry Deck (20):
1

what are the 6 classes of enzymes?

oxidoredictases, lyases, hydrolases, ligases, transferases, isomerases

2

what are the 4 classes of proteases?

metallo-, cysteine, aspartic, serine

3

what inactivates serine proteases?

serpins

4

how do serpins work?

bind to serine proteases as a "substrate" and cause an irreversible conformational change which inhibits the enzyme

5

how are proteases activated?

proteolytic cleavage

6

what are the 3 stages of a protease?

prepro-enzyme, pro-enzyme, mature protease

7

what are the two functions of a metal ion?

structural: helps protein stay folded
catalytic: participates in chemistry at the active site of the protein

8

what do oxidoreductases do?

catalyze redox reactions

9

what are common oxidoreductase names?

dehydrogenase, peroxidase, reductase, oxidase, hydroxylase, cytp450, oxygenase

10

what do transferases do?

move a group from one compound to another

11

what do hydrolases do?

break C-O,N,S bonds by cleaving water

12

what are common hydrolases?

protease, peptidase, esterase, phosphatase, urease

13

what do lyases do?

cleave C-C,O,N,S bonds by means other than hydrolysis

14

what are the reverse lyases called?

synthases

15

what are common lyase names?

decarboxylase, aldolase

16

what do isomerases do?

change structure without cleaving or adding anything

17

what do ligases do?

form C-C,O,N,S bonds w/ ATP

18

what are common ligase names?

synthetase, ligase

19

what makes up a serine proteases active site?

ser-Asp-His catalytic triad

20

what are 2 clinically important serps?

anti thrombin: inhibits coagulation
alpha-1-antitrypsin: inhibits neutrophil elastases in lungs (protective)