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Flashcards in Enzymes Deck (13):
1

What does 11-ß-Hydroxylase do?

11-Deoxycorticosterone --> Corticosterone
11-Deoxycortisol --> Cortisol

2

What does 11-ß-Dehydrogenase do?

Cortisol --> Cortisone

3

What does 17-alpha-Hydroxylase do?

Pregnenolone --> 17-alpha-Hydroxypregnenolone
Progesterone --> 17-alpha-Hydroxyprogesterone

4

What does 21-alpha-Hydroxylase do?

Progesterone --> 11-Deoxycorticosterone
17-alpha-Hydroxyprogesterone --> 11-Deoxycortisol

5

What does COMT do?

Epi --> Metanephrin
Nepi --> Normetanephrin

6

What does PMNT do?

Nepi --> Epi

7

What does Phospholipase A2 do?

Liberates Arachidonic Acid for synthesis of prostaglandins and leukotrienes (inhibited by lipocortin which is released by glucocorticoids)

8

What does 24-Hydroxylase do?

25-OH-Cholecalciferol --> 24, 25-OH-Cholecalciferol (in kidney)

9

What does 1-alpha-Hydroxylase (CYP1-alpha) do?

25-OH-Cholecalciferol --> 1, 25-Di-OH-Cholecalciferol (in kidney)

10

What does 25-Hydroxylase do?

Cholecalciferol (D3) --> 25-OH-Cholecalciferol (in liver)

11

What does 5'-Iodinase/Deiodinase types 1 and 2 do?

T4 --> T3 at target tissue

12

What does Thyroid Peroxidase do?

Iodide (I-) --> Iodine (I2)
I2 + TG --> MIT/DIT
DIT + DIT --> T4
DIT + MIT --> T3

13

What does Thyroid Deiodinase do?

MIT/DIT --> Tyr and I-