Eph/ephrin signalling pathway Flashcards Preview

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Flashcards in Eph/ephrin signalling pathway Deck (7)
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1
Q

What are EPH receptors and what family are they from?

A

EPH receptors are trans-membrane proteins from the Receptor Tyrosine Kinase family.

2
Q

What does downstream transduction of the signal involve?

A

Downstream transduction of the signal involves the oligomerisation and cytoplasmic cross-phosphorylation of the receptors.

3
Q

How are EPHs classified and according to what?

A

EPHs are classified in type-A and type-B, according to the Ephrin ligand they bind to

4
Q

What are ephrin-A ligands attached to?

A

Ephrin-A ligands are attached to the membrane by a lipid modification

5
Q

What are ephrin-B ligads?

A

Ephrin-B ligands are transmembrane proteins

6
Q

What can EPH receptors bind to either of and what exception is there?

A

EPH receptors can only bind to either Ephrin-A or Ephrin-B ligands, with one exception: EPHA4, which can bind to both types of ligands.

7
Q

What does an interaction between Ephrin ligands and EPH receptors lead to?

A

The interaction between Ephrin ligands and EPH receptors leads to a bidirectional response – in both the receiving and the signalling cell.