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FA Pharm > Epilepsy Drug MOA > Flashcards

Epilepsy Drug MOA Flashcards

1
Q

ethosuximide

A

blocks thalamic T type Ca2+ channels

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2
Q

benzodiazepines (diazepam, lorazepam)

A

increase GABA-A action

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3
Q

phenytoin

A

increase Na+ channel inactivation

zero order kinetics

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4
Q

carbamazepine

A

increase Na+ channel inactivation

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5
Q

valproic acid

A

increase Na+ channel inactivation

increase GABA concentration by inhibiting GABA transaminase

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6
Q

gabapentin

A

inhibits high voltage activated Ca2+ channels

GABA analog

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7
Q

phenobarbital

A

increase GABA-A action

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8
Q

topiramate

A

blocks Na+ channels

increase GABA action

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9
Q

lamotrigine

A

blocks voltage gated Na+ channels

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10
Q

levetiracetam

A

unknown - may modulate GABA and glutamate release

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11
Q

tiagabine

A

increase GABA by inhibiting reuptake

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12
Q

vigabatrin

A

increase GABA by irreversibly inhibiting GABA transaminase

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FA Pharm (3 decks)

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