Epithelial Glands: cytomembranes Flashcards Preview

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Flashcards in Epithelial Glands: cytomembranes Deck (32):
1

The Major Phopholipids of the Plasma Membrane are..

Phosphatidlycholine

Phosphatidylethanolamine

Phosphatidylserine 

Sphingomyelin

Phosphatidylinsoitol (inner Leaflet)

 

2

The interior of the plasma membrane is 

hydrophobic

3

The plasma membrane is made up of

lipids 

proteins

4

What do channel proteins let pass through

ions

ligand gated

 

5

What to carrie proteins let pass through

sugars

amino acids

nucleosides

6

Faccilitated diffusion

glucose

small ions

charged moelecules

7

Secretory protein pathway

rer

cis golig apparatus

secretory vesicles

lumen

8

The Luminal/ endoplasmic part of the ER correlates with

the exterior of the cell

9

The protplasmic sufaces faces the 

cytosol

10

The extraceullar sufaces faces the 

lumen

11

When you spilt the plams membrane you get

surfaces

12

KDEL

signal that enables you to be retained in the ER

13

Trans golgi Network

sorting of proteins to the lysosomal or exocytosis pathway

14

Faculative

regulated secretion

15

Cargo Sorting

Microtubules

Actin Filaments

16

Golgi Appartus Functions

1. modification of carbohydrates attached to glycoproteins and proteoglycans (from ER)

2. sorting of cargo to different destinations

3. sythesis of SPHINGOMYELIN

17

Clathrin

Dynamin(pinches off)

Adaptins (stabilize clathrin coat)

Basket arrangment

recyled after transport into plasma membrane

18

Clathrin Coated Vesicles 

Trans golgi to lysosomes

External Cell to lysosomes

*Adaptin ( helps form clathrin coat on vesicle)

19

COP-coated

Er to golgi (COP II)

Cis golgi trans to golgi network (COP I)

ARF-GTP: helps form coatmer on cytosolic side of vesicle 

ARF-GDP vesicle binds to plasma membrane

20

Vesicle Fusion

Recogntion: V-SNARE (vesicle) 

+

T-SNARE (target membrane)

 

 

Fusion: NSF+SNAPS

 

*SNARES=SNAP RECEPTORS 

21

Lysosomal Storing pathway 

Lysosomal hydrolase (made in ER)

then

Add M6P (cis golgi)

then

M6P receptor (trans golgi network)

then 

by method of clathrin coated vesicle (primary lysosome)

 

22

Endocytosis

Clathrin free phagosomes

Clathrin coated 

pincocytosis

23

Clathrin-Coated 

small macromolecules

24

Pinocytosis

cells dinking fluid

*caveolin*

25

Clathrin free phagosomes

large particles

(virus, bacteria,debris)

26

Receptor Mediated Endocytosis of cholestoral

LDL receptor/comples

clathrin 

endosome

primary lysosome

secondary lysosomes

LDL receptor recyled 

 

**Familial hypercholesterolemia (mut of LDL receptor)

**cholestoral usually insoluable

27

Mitocondria 

most mitocondria proteins encoded in cytosol ribosomes then transported into mitocondria by targeting signals

TARGET into mictocondria: TOM, Hsp 60, Hsp 70

 

Oxidative phosphorylation

Outer membrane(permeable) porins

Inner membrane (ETC)

 

 

 

28

Functions of Mitocondria

1. apoptosis: procapsases 2,3,9

steroidgenisis

thermogensis (uncoupling) prton leak UCP-1 (BROWN FAT)

 

29

Where do you get your mitocondrial DNA from?

mother 

30

What is MERRF 

issue with mitocondrial dna

pt mutation of tRNA for lysine

31

Peroxisomes

H202 catalase breaks down to H20

zwelleger syndrome

single membrane bound

liver

proteins for peroxisome made in cytopasm

Target Sequence : ser-lys-leu

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