Epithelial Tumours Of The Skin Flashcards Preview

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Flashcards in Epithelial Tumours Of The Skin Deck (18)

What virus causes warts

Human papilloma virus


What are the clinical types of viral warts (4)

Verruca Vulgaris
Verruca plana
Verruca plantaris
Condyloma acuminatum


How does molluscum contagiosum present, what virus is it caused by, how is it spread, who is it most common in?

Umbilicated papules caused by pox virus, spread by direct contact, infects follicular infundibular, typically resolved
Affects children and young adults


How does solar lentigo appear and what are some of its features (hint keratinocytes, melanocytes features)

Pigmented macules (flat lesion) on sun exposed skin.
Elongation of rete ridges, keratinocyte hyperpigmentation
Variable minimal melanocytes proliferation


Where does seborrheic keratosis usually occur on the body, and what kind of surface does it have?

Trunk, forehead
Waxy surface (sharply demarcated, "stuck on")


What are 3 common types of seborrheic keratosis

- acanthotic
- papillomatous/hyperkeratotic
- reticular


What are some differences between epidermal cysts and tricholemmal cysts?

Epidermal cysts - usually affect the trunk/neck/face, have a punctum (opening to the surface), rupture with keratin granuloma is common

Tricholemmal cysts - usually on the scalp, have no punctum, lacks granular layer, rarely proliferating


What is the most common type of skin cancer

Basal cell carcinoma


Where do basal cell carcinomas predominantly occur?

Sun damaged skin
Most common on head and neck, followed by the trunk


What are some of the morphological differences between superficial and nodular basal cell carcinomas

Superficial - appear patchy, red, less distinct but bigger than nodular

Nodular - pearly appearance, central area of ulceration with rolled margin


What is actinic keratosis

Dysplastic proliferation of keratinocytes


What is actinic keratosis a marker of and what is it a risk for

Marker of solar damage and risk of skin cancer


What type of skin and in what age does actinic keratosis most commonly occur

Sun exposed sites, fair skin, middle aged/elderly


What type of skin can intra-epidermal squamous cell carcinoma occur on and how does it appear

Sun exposed or sun protected
Erythematous plaque, cytological atypia (cells pleomorphic), and adnexal colonisation -colonisation of structures that are closely related to where the lesion originated


What are high risk sites for squamous cell carcinoma

Ear, lips, vulva and penis - mucocutaneous junctions have a higher risk of SCC metastases


What are risk factors for squamous cell carcinoma

Clinical size more than 2cm
More than 2mm thickness
Clark level 4 or 5
Poorly differentiated


What type of skin does squamous cell carcinoma occur on and what are its characteristics (eg when you palpate it) and what is its risk for metastasis

Sun damaged skin
Tenderness, thickness on palpating
Low risk for metastasis


What is a keratoacanthoma

Rapidly growing crateriform lesion. Usually involutes.
Clinical and histological overlap with some types of SCC

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